辅酶 Q10 对阿霉素引起的白化病大鼠心肺轴缺陷的组织学影响。
HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS.
发表日期:2024 Apr
作者:
Sh Ali, E Sulaiman, S Dhiaa
来源:
ANTIOXIDANTS & REDOX SIGNALING
摘要:
阿霉素是常见的化疗药物,已用于治疗各种类型的恶性肿瘤,包括治疗软组织和骨肉瘤以及乳腺癌、卵巢、膀胱和甲状腺等重要器官的癌症。它也用于治疗白血病和淋巴瘤,然而,这是一个障碍,因为它们具有显着的副作用,包括心脏毒性和肺纤维化,我们的目标是确定 CoQ10 作为抗氧化剂在阻止阿霉素对组织的有害影响方面的作用退化效应。为此,27 只大鼠被分为 3 组,每组 9 只; CoQ10暴露组、阿霉素暴露组和CoQ10加阿霉素组。研究结束时,处死动物,收获肺和心脏,并制备载玻片用于显微镜下检查。结果表明,阿霉素诱导异常的细胞结构,导致肺和心脏的细胞结构受损,而辅酶Q10则阻止这些损害作用并几乎恢复正常的组织结构。因此,CoQ10 将维持肺和心脏的正常组织。
Doxorubicin is the common chemotherapeutic agent that has been harnessed for the treatment of various types of malignancy including the treatment of soft tissue and osteosarcoma and cancers of the vital organs like breast, ovary, bladder, and thyroid. It is also used to treat leukaemia and lymphoma, however, this is an obstacle because of their prominent side effects including cardiotoxicity and lung fibrosis, we do aim to determine the role of CoQ10 as an antioxidant on the impeding the deleterious impacts of doxorubicin on tissue degenerative effects. To do so, 27 rats were subdivided into 3 groups of 9 each; CoQ10 exposed group, Doxorubicin exposed group, and CoQ10 plus Doxorubicin group. At the end of the study, the animals were sacrificed and lungs with hearts were harvested, and slides were prepared for examination under a microscope. The results indicated that doxorubicin induced abnormal cellular structure resulting in damaging cellular structures of the lung and heart while CoQ10 impeded these damaging effects and nearly restoring normal tissue structure. As a result, CoQ10 will maintain normal tissue of the lung and heart.