关于微乳头成分对乳腺癌预后影响的数据有限。本研究的目的是调查纯性和混合性浸润性微乳头状乳腺癌 (IMPC) 患者与浸润性导管癌 (IDC) 患者相比的临床病理学特征和长期结果。这项回顾性研究分析了在该中心接受治疗的所有 IMPC 和 IDC 患者。 1997 年至 2019 年间欧洲肿瘤研究所 (IEO) 的数据。IMPC 患者的总体队列分为两组：纯 IMPC 和混合 IMPC。根据手术年份、年龄、pT、pN 和分子亚型，将每名混合或纯 IMPC 患者与一名 IDC 患者相匹配。总共 30,115 名 IDC、120 名纯 IMPC 和 150 名混合 IMPC 患者被认为符合资格。与 IDC 相比，纯 IMPC 和混合 IMPC 患者局部晚期疾病（pT2-T3、pN2-N3）、血管侵犯和 Luminal B 亚型的发生率更高。匹配后，与 IDC 患者相比，纯 IMPC 和混合 IMPC 显示出显着更高的血管侵犯率 (p<<0.001)。与单纯 IMPC 患者相比，IDC 患者的无侵袭性疾病生存率更高 (p = 0.11)。与 IDC 组相比，纯 IMPC 组的长期总生存率显着较差 (p = 0.004)，而混合 IMPC 与匹配 IDC 组的长期总生存率相似 (p = 0.07)。这些真实世界数据报告了纯 IMPC 组的预后较差IDC 强调了微乳头亚型本身在 IMPC 管理决策过程中的独特预后价值。准确的术前诊断评估和多学科方法对于最佳个性化治疗至关重要。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

Data on the prognostic impact of the micropapillary component in breast cancer are limited. The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of pure and mixed invasive micropapillary breast cancer (IMPC) patients compared to invasive ductal cancer (IDC) patients.This retrospective study analysed all IMPC and IDC patients treated at the European Institute of Oncology (IEO) between 1997 and 2019. The overall cohort of IMPC patients was divided in two groups, pure and mixed IMPC. Each patient with mixed or pure IMPC was matched with one patient with IDC, based on year of surgery, age, pT, pN, and molecular subtype.A total of 30,115 IDC, 120 pure IMPC and 150 mixed IMPC patients were considered eligible. Compared to IDC, pure and mixed IMPC patients presented a higher rate of locally advanced disease (pT2-T3, pN2-N3), vascular invasion, and Luminal B subtype. After matching, pure and mixed IMPC showed a significant higher rate of vascular invasion compared to IDC patients (p < 0.001). Invasive disease-free survival was better in IDC compared to pure IMPC patients (p = 0.11). Long-term overall survival was significantly worse in pure IMPC group compared to IDC group (p = 0.004), being instead similar between mixed IMPC vs matched IDC (p = 0.07).These real-world data reported the worse prognosis of pure IMPC compared to IDC, highlighting the peculiar prognostic value of the micropapillary subtype itself in the decision-making process of IMPC management. An accurate pre-surgical diagnostic evaluation and a multidisciplinary approach are pivotal to best personalize its treatment.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.