内分泌干​​扰化学品 (EDC) 是一种持久且普遍存在的化合物，会带来严重风险。许多研究探讨了 EDC 对人类健康的影响，其中肿瘤是主要关注点。然而，由于研究设计缺陷、缺乏有效的 EDC 暴露水平以及不一致的人群数据和研究结果，很难就这些化合物对肿瘤相关结果的影响得出明确的结论。我们的研究首次系统整合了 20 多年来的观察性研究和随机对照试验，并总结了 300 多个亚组关联。我们发现大多数 EDC 会促进肿瘤的发展，而居住环境污染物的暴露可能是农药暴露的主要来源。此外，我们发现植物雌激素具有抗肿瘤作用。这项研究的结果有助于制定全球 EDC 监管健康政策，并减轻与 EDC 暴露相关的严重风险。版权所有 © 2024 Elsevier B.V。保留所有权利。

Endocrine-disrupting chemicals (EDCs) are persistent and pervasive compounds that pose serious risks. Numerous studies have explored the effects of EDCs on human health, among which tumors have been the primary focus. However, because of study design flaws, lack of effective exposure levels of EDCs, and inconsistent population data and findings, it is challenging to draw clear conclusions on the effect of these compounds on tumor-related outcomes. Our study is the first to systematically integrate observational studies and randomized controlled trials from over 20 years and summarize over 300 subgroup associations. We found that most EDCs promote tumor development, and that exposure to residential environmental pollutants may be a major source of pesticide exposure. Furthermore, we found that phytoestrogens exhibit antitumor effects. The findings of this study can aid in the development of global EDCs regulatory health policies and alleviate the severe risks associated with EDCs exposure.Copyright © 2024 Elsevier B.V. All rights reserved.