宫颈食管癌内镜粘膜下剥离术（ESD）后狭窄的发生率很高。我们的目的是阐明狭窄的危险因素，并评估类固醇注射预防颈段食管狭窄的疗效。我们回顾性分析了 100 例因颈段食管癌接受 ESD 的患者，目的是：（1）确定与颈段食管狭窄相关的因素。没有接受类固醇注射； (2) 比较接受类固醇注射和未接受类固醇注射的患者狭窄的发生率。在 48 名未接受类固醇注射的患者中，肿瘤大小 (P = .026)、切除时间 (P = .028) 和手术时间有显着差异。狭窄患者 (n = 5) 和无狭窄患者 (n = 43) 之间粘膜缺损的圆​​周范围 (P = .005)。与未注射类固醇的患者相比，当 ESD 后粘膜缺损 < 3/4 和 ≥ 1/2 时，注射类固醇的患者狭窄发生率显着降低（40% vs 8%，P = .039）。对于ESD后粘膜缺损≥3/4的患者（n = 13），所有患者均进行了局部类固醇注射，其中6例患者（46%）出现狭窄。接受≥1/2环周的患者切除者发生颈段食管狭窄的风险较高。类固醇注射对 < 3/4 和 ≥ 1/2 圆周切除的患者具有预防狭窄的作用，但对于 ≥ 3/4 圆周切除的患者似乎不足以预防狭窄。版权所有 © 2024 美国胃肠内镜学会。由爱思唯尔公司出版。保留所有权利。

There is a high incidence of stricture after endoscopic submucosal dissection (ESD) for cervical esophageal cancer. We aimed to elucidate the risk factors for stricture and evaluate the efficacy of steroid injection for stricture prevention in the cervical esophagus.We retrospectively analyzed 100 patients who underwent ESD for cervical esophageal cancer to: (1) identify the factors associated with stricture among patients who did not receive steroid injection; (2) compare the incidence of stricture between patients with and without steroid injection.Among 48 patients who did not receive steroid injection, there were significant differences in tumor size (P = .026), resection time (P = .028), and circumferential extent of the mucosal defect (P = .005) between patients with stricture (n = 5) and without stricture (n = 43). Compared with patients without steroid injection, patients with steroid injection had a significantly lower incidence of stricture when the post-ESD mucosal defect was < 3/4 and ≥ 1/2 (40% versus 8%, P = .039). As for the patients with a post-ESD mucosal defect of ≥ 3/4 (n = 13), local steroid injection was performed for all the patients, and 6 patients (46%) developed stricture.Patients who underwent ≥ 1/2 circumferential resection were at high risk of cervical esophageal stricture. Steroid injection had a stricture-prevention effect in patients with < 3/4 and ≥ 1/2 circumferential resection, but seemed to be insufficient in preventing stricture in patients with ≥ 3/4 circumferential resection.Copyright © 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.