多酚类物质因其丰富的抗氧化、抗炎、抗肿瘤等功能活性而受到广泛关注。然而，低溶解度和差的稳定性限制了它们的生物利用度和功能活性。植物源性铁蛋白笼具有独特的中空笼结构，可以嵌入多酚以改善其不利特性。因此，有必要充分阐述和总结植物源性铁蛋白笼，以最大限度地发挥其在营养干预方面的潜在益处。本文重点综述了植物源铁蛋白笼的基本特性，包括制备工艺、纯化技术、鉴定方法以及结构和功能特性。综述了铁蛋白笼在多酚递送中的相关研究，包括水/脂溶性多酚的递送、铁蛋白笼的修饰以及多酚与铁蛋白笼之间的相互作用。介绍了植物源铁蛋白笼在精准营养领域的研究进展、不足及展望。此外，还探讨了铁蛋白在免疫反应和蛋白质工程中的相关研究，为植物源铁蛋白笼在多个前沿领域的应用提供理论基础。Copyright © 2024 Elsevier B.V. 保留所有权利。

Polyphenols have attracted extensive attention due to their rich functional activities, such as antioxidant, anti-inflammatory and anti-tumor. However, the low solubility and poor stability limit their bioavailability and functional activities. Plant-derived ferritin cages have a unique hollow cage structure that can embed polyphenols to improve their unfavorable properties. Therefore, it is essential to adequately elaborate and summarize plant-derived ferritin cages to maximize their potential benefits in nutritional interventions. This review focuses on the fundamental properties of plant-derived ferritin cages, including the preparation process, purification technology, identification methods, and structural and functional properties. The relevant research on ferritin cages in polyphenol delivery has been summarized, including the delivery of water/lipid soluble polyphenols, modification of ferritin cages, and the interaction between polyphenols and ferritin cages. The research progress, shortcomings and prospects of plant-derived ferritin cages in precise nutrition are introduced. In addition, the relevant research on ferritin in immune response and protein engineering is also discussed to provide the theoretical basis for applying plant-derived ferritin cages in many frontier fields.Copyright © 2024 Elsevier B.V. All rights reserved.