细胞周期蛋白依赖性激酶样（CDKL）家族蛋白是丝氨酸/苏氨酸蛋白激酶，是CMGC（包括CDK、MAPK、GSK）的一个特定分支。因其与CDK的序列相似而得名，由5个成员组成。它们在蛋白质磷酸化中的功能巩固了它们在细胞活动中的重要作用，包括细胞周期、细胞凋亡、自噬和微管动力学。 CDKL 蛋白已被证明可以调节初级纤毛的长度，初级纤毛是一个动态且多样化的信号中枢，与多种疾病密切相关。此外，CDKL 蛋白已被证明参与多种疾病的发生和进展，包括癌症、神经退行性疾病和肾脏疾病。在这篇综述中，我们总结了 CDKL 蛋白的结构特征、发现的功能及其在疾病中的作用，这可能有助于开发疾病的创新治疗策略。版权所有 © 2024。由 Elsevier B.V. 出版。

Cyclin-dependent kinase-like (CDKL) family proteins are serine/threonine protein kinases and is a specific branch of CMGC (including CDK, MAPK, GSK). Its name is due to the sequence similarity with CDK and it consists of 5 members. Their function in protein phosphorylation underpins their important role in cellular activities, including cell cycle, apoptosis, autophagy and microtubule dynamics. CDKL proteins have been demonstrated to regulate the length of primary cilium, which is a dynamic and diverse signaling hub and closely associated with multiple diseases. Furthermore, CDKL proteins have been shown to be involved in the development and progression of several diseases, including cancer, neurodegenerative diseases and kidney disease. In this review, we summarize the structural characteristics and discovered functions of CDKL proteins and their role in diseases, which might be helpful for the development of innovative therapeutic strategies for disease.Copyright © 2024. Published by Elsevier B.V.