心血管健康被认为是癌症幸存者最关心的问题。社会经济地位（SES）是心血管疾病（CVD）的一个重要但经常被忽视的危险因素。我们进行这项研究的目的是确定癌症幸存者中 SES 与 CVD 死亡率之间的关系。利用国民健康保险服务-国民健康检查者数据库，我们确定了癌症幸存者的诊断和诊断后存活超过 5 年的情况。 SES 根据保险费进行评估，分为 5 组。主要结局是心血管疾病总体死亡率。这项研究分析了 170,555 名个体（平均年龄 60.7 ± 11.9 岁，57.8% 为女性）。在 SES 组中观察到风险逐渐增加：总体 CVD 死亡率的调整后风险比（95% 置信区间）分别为 1.15 (1.04-1.26)、1.28 (1.15-1.44)、1.31 (1.18-1.46) 和 2.13 (1.30) -3.49）分别为第二、第三和第四四分位数以及医疗援助组（最低 SES 组）与最高 SES 组的比较（趋势 p < 0.001）。与不患有高血压的 SES 最高组相比，患有高血压的 SES 最低组的 CVD 死亡风险高出 3.4 倍。相互作用分析显示，低 SES 与高血压存在协同相互作用，增加 CVD 死亡率的风险（协同指数 1.62）。这项研究表明，低 SES 与癌症幸存者 CVD 死亡率增加之间存在显着相关性。特别是，SES 最低的人群如果与高血压合并，会显着增加 CVD 死亡率。我们的研究结果强调了认识到 SES 作为癌症幸存者群体 CVD 死亡的重要危险因素的至关重要性。© 作者 2024。由牛津大学出版社代表欧洲心脏病学会出版。

Cardiovascular health is acknowledged as a crucial concern among cancer survivors. Socioeconomic status (SES) is an essential but often neglected risk factor for cardiovascular disease (CVD). We conducted this study to identify the relationship between SES and CVD mortality in cancer survivors.Using the National Health Insurance Service-National Health Examinee database, we identified cancer survivors diagnosed and surviving beyond 5 years post-diagnosis. SES was assessed based on insurance premiums and classified into 5 groups. The primary outcome was overall CVD mortality. This study analyzed 170 555 individuals (mean age 60.7 ± 11.9 years, 57.8% female). A gradual increase in risk was observed across SES groups: adjusted hazard ratios (95% confidence intervals) for overall CVD mortality were 1.15 (1.04-1.26), 1.28 (1.15-1.44), 1.31 (1.18-1.46), and 2.13 (1.30-3.49) for the second, third, and fourth quartile, and medical aid group (the lowest SES group) compared to the highest SES group, respectively (p for trend < 0.001). The lowest SES group with hypertension exhibited a 3.4-fold higher risk of CVD mortality compared to the highest SES group without hypertension. Interaction analyses revealed that low SES synergistically interacts with hypertension, heightening the risk of CVD mortality (synergy index 1.62).This study demonstrates a significant correlation between low SES and increased CVD mortality among cancer survivors. Particularly, the lowest SES group, when combined with hypertension, significantly escalates CVD mortality. Our findings underscore the critical importance of recognizing SES as a significant risk factor for CVD mortality in this population of cancer survivors.© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.