更新和扩展丹麦消防员队列的癌症发病率检查，现在增加了 7 年的随访和 2766 名额外的消防员。主要关注点是最近为国际癌症研究机构 (IARC) 进行的危害评估做出贡献的癌症场所。更新的队列由 11,827 名丹麦男性消防员组成，他们从 1968 年到 2021 年接受了癌症随访。将发病率与工作人群参考组进行比较，并使用标准化发病率 (SIR) 以及 95% 置信区间 (95% CI) 来估计相对风险。在全职消防员中，皮肤黑色素瘤的 SIR 为 1.30（ 95% CI: 1.02-1.66)，工作时间超过 5 年的 SIR = 1.37 (95% CI: 1.02-1.85)。膀胱癌（SIR = 1.16；95% CI：0.93-1.45）、前列腺癌（SIR = 1.11；95% CI：0.97-1.28）和睾丸癌（SIR = 1.11；95%）也观察到轻微正相关。 CI：0.75-1.63）。这项最新研究提供的证据表明消防员患皮肤黑色素瘤的风险较高。与 IARC 的评估一致，我们还发现与膀胱癌、前列腺癌和睾丸癌呈正相关。相反，我们的研究结果并未表明结肠癌、非霍奇金淋巴瘤和间皮瘤的风险增加。后者可能是由于我们仍然相对年轻的群体中人数较少。有必要对消防员的癌症进行持续随访，包括评估监测偏差的影响。© 2024 Wiley periodicals LLC。

To update and extend the examination of cancer incidence in a cohort of Danish firefighters, now adding 7 years of follow-up and 2766 additional firefighters. The primary focus was directed toward cancer sites that recently contributed to the hazard evaluation conducted by the International Agency for Research on Cancer (IARC).The updated cohort consisted of 11,827 male Danish firefighters who were followed up for cancer from 1968 to 2021. Cohort cancer morbidity was compared with a working population reference group, and standardized incidence ratios (SIR) were used for estimation of relative risks, along with 95% confidence intervals (95% CI).Among full-time firefighters, SIR of skin melanoma was 1.30 (95% CI: 1.02-1.66), and SIR = 1.37 (95% CI: 1.02-1.85) for over 5 years of employment. Slightly positive associations were also observed for cancer of the urinary bladder (SIR = 1.16; 95% CI: 0.93-1.45), prostate (SIR = 1.11; 95% CI: 0.97-1.28), and testis (SIR = 1.11; 95% CI: 0.75-1.63).This updated study provides evidence indicating an elevated risk of skin melanoma in firefighters. Consistent with IARC's evaluation, we also identified positive associations for urinary bladder, prostate, and testis cancer. In contrast, our findings did not suggest an increased risk of colon cancer, non-Hodgkin lymphoma, and mesothelioma. The latter may be due to small numbers in our still relatively young cohort. Continuous follow-up for cancer in firefighters is warranted, including assessment of influence from surveillance bias.© 2024 Wiley Periodicals LLC.