弥漫性硬化变异（DSV）是甲状腺乳头状癌（PTC）的侵袭性变异之一，在儿童患者中比在成人患者中更常见。由于其发病率低，很少有研究评估其特征。我们的目的是评估 PTC DSV 复发与年龄之间的关系。我们回顾性分析了 1988 年 5 月至 2019 年 1 月在医疗中心手术后诊断为 DSV 或传统 PTC (cPTC) 的患者。我们比较了临床病理特征DSV 和 cPTC 组以及成人和儿童 DSV 患者之间的手术结果。在 24,626 名患者中，202 名患有 DSV，24,424 名被诊断为 cPTC。 DSV 组的复发率显着高于 cPTC 组。在DSV组中，儿童患者组的复发率显着高于成人患者组。此外，复发与年龄组之间的关联在具有受限三次样条（RCS）的 DSV 组和 cPTC 组之间显示出不同的模式。虽然两条 RCS 曲线均呈 U 形分布，但 RCS 曲线往往位于较年轻的年龄组内。这项研究表明，与成人患者相比，DSV 儿童患者的复发风险更大；此外，根据年龄的复发风险模式与 cPTC 不同。版权所有 © 2024 Kim, Koo, Bang, Kim, Kang, Jeong, Nam 和 Chung。

The diffuse sclerosing variant (DSV) is among the aggressive variants of papillary thyroid carcinoma (PTC) and is more prevalent in pediatric patients than in adult patients. Few studies have assessed its characteristics owing to its low incidence. We aimed to evaluate the relationship between recurrence and age in the DSV of PTC.We retrospectively reviewed patients diagnosed with the DSV or conventional PTC (cPTC) after surgery at a medical center between May 1988 and January 2019. We compared the clinico-pathological characteristics and surgical outcomes of the DSV and cPTC groups and between adult and pediatric patients with DSV.Among the 24,626 patients, 202 had the DSV, and 24,424 were diagnosed with cPTC. The recurrence rate was significantly higher in the DSV group than in the cPTC group. In the DSV group, the recurrence rate was significantly higher in the pediatric patient group than in the adult patient group. Moreover, the association between recurrence and age group showed different patterns between the DSV and cPTC groups with restricted cubic splines (RCS). While both RCS curves showed a U-shaped distribution, the RCS curve tended to be located within the younger age group.This study demonstrated that pediatric patients with DSV are at a greater risk for recurrence compared with adult patients; moreover, the pattern of recurrence risk according to age is different from that of cPTC.Copyright © 2024 Kim, Koo, Bang, Kim, Kang, Jeong, Nam and Chung.