博莱霉素是一种糖肽类抗生素，具有突出的抗肿瘤作用。博莱霉素的主要副作用是肺纤维化。然而，白内障的严重不良反应尚未见报道。本文中，我们描述了首例因博来霉素治疗而诱发白内障的病例，患者为一名患有睾丸癌的 22 岁男性。在手术干预和连续五个周期的 BEP 方案化疗（包括博来霉素、依托泊苷和顺铂）后，患者报告逐渐无痛性视力丧失，视觉能力大幅下降，尤其是右眼。经过全面的眼部检查，诊断出患有白内障。最终，患者接受了超声乳化吸除术并更换了人工晶状体。博莱霉素可引起白内障，从而导致视力严重丧失。因此，临床医生应观察早期症状，适当调整治疗，防止症状加重。版权所有 © 2024 张、吉、孙、智、杨、张、卢、张。

Bleomycin is a glycopeptide antibiotic with outstanding anti-tumor effects. A major adverse effect of bleomycin is lung fibrosis. However, the development of cataracts as a severe adverse effect has not been reported.Herein, we describe the first case of cataract induced by bleomycin therapy in a 22-year-old male with testicular cancer. After surgical intervention and following five successive chemotherapy cycles of the BEP regimen, including bleomycin, etoposide and cisplatin, the patient reported a gradual painless loss of vision, with substantial decline in visual ability, especially in the right eye. Following comprehensive eye examinations, a cataract was diagnosed. Eventually, the patient underwent phacoemulsification and received replacement of the intraocular lenses.Bleomycin can cause cataracts, which induces a significant loss of vision. Therefore, clinicians should observe early symptoms and properly adjust treatment to prevent aggravation of symptoms.Copyright © 2024 Zhang, Ji, Sun, Zhi, Yang, Zhang, Lu and Zhang.