全球早发性结直肠癌（EOCRC）的发病率正在增加。本研究旨在基于 GBD 2019 描述国家层面的发病率时间趋势并探讨生命早期的相关风险暴露。 EOCRC 发病率和可归因危险因素的数据来自 GBD 2019。 年龄的时间趋势-通过平均年百分比变化（AAPC）评估标准化发生率。生命早期暴露以所选因素、SDI 和前几十年以及 0-4、5-9、10-14 和 15-19 岁时人均 GDP 的汇总暴露值 (SEV) 表示。应用加权线性或非线性回归来评估暴露与 EOCRC 发病率的生态总体关联。 1990 年，全球 EOCRC 年龄标准化发病率从每 10 万人 3.05 (3.03, 3.07) 增加到 3.85 (3.83, 3.86) 2019年和2019年。在社会经济水平较高的国家，发病率较高，在东亚和加勒比国家，特别是牙买加、沙特阿拉伯和越南，发病率急剧上升。早年的人均GDP、SDI、缺铁、饮酒、高体重指数、儿童生长障碍的SEV与2019年EOCRC的发病关系更为密切。 0-4岁、5-5岁暴露情况9、10-14 和 15-19 岁也与发病率相关，特别是 15-19 岁的暴露。在过去三十年中，全球 EOCRC 发病率有所增加。地区和国家层面的巨大差异可能与生命早期风险暴露的分布有关。版权所有 © 2024 Wang, Yao, Wu, Huang, Ma, Yang, Shi, Fu, Wang, Wong and Xu.

The incidence of early-onset colorectal cancer (EOCRC) is increasing globally. This study aims to describe the temporal trends of incidence and explore related risk exposures in early-life at the country level based on the GBD 2019.Data on the incidence and attributable risk factors of EOCRC were obtained from the GBD 2019. Temporal trends of age-standardized incidence were evaluated by average annual percentage change (AAPC). Early-life exposures were indicated as summary exposure values (SEV) of selected factors, SDI and GDP per capita in previous decades and at ages 0-4, 5-9, 10-14 and 15-19 years. Weighted linear or non-linear regressions were applied to evaluate the ecological aggregate associations of the exposures with incidences of EOCRC.The global age-standardized incidence of EOCRC increased from 3.05 (3.03, 3.07) to 3.85 (3.83, 3.86) per 100,000 during 1990 and 2019. The incidence was higher in countries with high socioeconomic levels, and increased drastically in countries in East Asia and Caribbean, particularly Jamaica, Saudi Arabia and Vietnam. The GDP per capita, SDI, and SEVs of iron deficiency, alcohol use, high body-mass index, and child growth failure in earlier years were more closely related with the incidences of EOCRC in 2019. Exposures at ages 0-4, 5-9, 10-14 and 15-19 years were also associated with the incidences, particularly for the exposures at ages 15-19 years.The global incidence of EOCRC increased during past three decades. The large variations at regional and national level may be related with the distribution of risk exposures in early life.Copyright © 2024 Wang, Yao, Wu, Huang, Ma, Yang, Shi, Fu, Wang, Wong and Xu.