尽管黑色素瘤仅占皮肤癌的 1%，但它却是大多数皮肤癌死亡的原因。多形性胶质母细胞瘤是一种高级星形细胞瘤，是最具侵袭性和破坏性的原发性脑肿瘤。这两种疾病仍然是皮肤病学和神经肿瘤学专业中最大的治疗挑战。一名 53 岁菲律宾男性，身体出现全身深棕色和黑色斑块已有 2 年历史，出现左肢无力和麻木。皮肤活检和免疫组织化学染色显示结节性黑色素瘤和邻近的消退性黑色素瘤。颅内肿块活检显示多形性胶质母细胞瘤。颅内肿块部分切除后1个月，患者因脑疝死亡。结节性黑色素瘤和多形性胶质母细胞瘤可能同时发生在患者身上。文献综述表明存在共同的遗传倾向。它的存在导致预后不良，需要早期发现才能开始积极治疗。© 2024 Acta Medica Philippina。

Although melanoma only accounts for 1% of skin cancers, it is responsible for most skin cancer deaths. Glioblastoma multiforme, a high-grade astrocytoma, is the most aggressive and devastating primary brain tumor. These two diseases remain to be the biggest therapeutic challenge in both specialties of dermatology and neuro-oncology. A 53-year-old Filipino male who presented with a 2-year history of generalized dark brown and black patches on the body developed weakness and numbness of the left extremities. Biopsy and immunohistochemical staining of the skin revealed nodular melanoma with adjacent regressing melanoma. Biopsy of the intracranial mass showed glioblastoma multiforme. One month after the partial excision of the intracranial mass, the patient expired due to brain herniation. Nodular melanoma and glioblastoma multiforme may occur concomitantly in a patient. A review of the literature suggests a shared genetic predisposition. Its existence carries a poor prognosis and requires early detection to start aggressive treatment.© 2024 Acta Medica Philippina.