免疫检查点疗法可以驱动抗肿瘤反应并使患者受益，但也可能诱发危及生命的免疫相关不良事件，例如心肌炎和肌炎。这些与免疫相关的不良事件很少见，但发病率和死亡率很高。在本期中，Siddiqui 及其同事使用单细胞 RNA 和 T 细胞受体测序来识别新的细胞亚群，并提出可能有助于免疫检查点抑制剂相关心肌炎和肌炎发病机制的各种机制。这些新见解应有助于推动该领域开发改进的治疗和预防方案，最终改善患者的治疗结果。参见 Siddiqui 等人的相关文章，第 17 页。 XX (1).©2024 美国癌症研究协会。

Immune checkpoint therapies can drive antitumor responses and benefit patients but can also induce life-threatening immune-related adverse events such as myocarditis and myositis. These immune-related adverse events are rare but carry substantial morbidity and mortality. In this issue, Siddiqui and colleagues use single-cell RNA and T-cell receptor sequencing to identify novel cellular subsets and propose various mechanisms that could contribute to the pathogenesis of immune checkpoint inhibitor-associated myocarditis and myositis. These new insights should help move the field toward the development of improved treatment and prevention options, ultimately improving patient outcomes. See related article by Siddiqui et al., p. XX (1).©2024 American Association for Cancer Research.