肠道微生物群具有丰富的多样化微生物，是人类生理和代谢稳态的重要组成部分，表明它们在宿主的一系列生理和病理过程中发挥着作用。维持肠道微生物群的平衡对于正常功能至关重要，因为微生物失调可通过各种机制导致疾病的发生和发展。长非编码RNA (lncRNA) 和环状RNA (circRNA) 是非编码RNA，对许多过程执行重要的调节功能。此外，已知肠道微生物群和 lncRNA/circRNA 在一系列生理和病理活动中相互作用。在本文中，我们回顾了与肠道微生物群和 lncRNA/circRNA 之间相互作用相关的现有研究，并研究了它们的串扰在不同疾病发病机制中的作用。研究表明，肠道菌群可以靶向lncRNA ENO1-IT1、BFAL1和LINC00152，通过多种信号通路调节结直肠癌的发展。此外，肠道菌群还可以通过调节circNF1-419、circ_0001239、circHIPK2和mmu_circ_0000730等circRNA来影响精神疾病和肺部肿瘤转移。这些发现为疾病预防和治疗提供了理论依据，并表明肠道微生物-lncRNA/circRNA串扰具有较高的临床价值。

The gut microbiota features an abundance of diverse microorganisms and represents an important component of human physiology and metabolic homeostasis, indicating their roles in a wide array of physiological and pathological processes in the host. Maintaining balance in the gut microbiota is critical for normal functionality as microbial dysbiosis can lead to the occurrence and development of diseases through various mechanisms. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are non-coding RNAs that perform important regulatory functions for many processes. Furthermore, the gut microbiota and lncRNAs/circRNAs are known to interact in a range of both physiological and pathological activities. In this article, we review existing research relevant to the interaction between the gut microbiota and lncRNAs/circRNAs and investigate the role of their crosstalk in the pathogenesis of different diseases. Studies have shown that, the gut microbiota can target lncRNAs ENO1-IT1, BFAL1, and LINC00152 to regulate colorectal cancer development via various signaling pathways. In addition, the gut microbiota can influence mental diseases and lung tumor metastasis by modulating circRNAs such as circNF1-419, circ_0001239, circHIPK2 and mmu_circ_0000730. These findings provide a theoretical basis for disease prevention and treatment and suggest that gut microbiota-lncRNA/circRNA crosstalk has high clinical value.