在免疫功能低下的宿主中，白血病患者和造血细胞移植受者尤其脆弱，面临着平衡 2019 年冠状病毒病 (COVID-19) 管理与其基础状况的挑战。在这篇《我如何治疗》文章中，我们讨论了如何在日常临床实践中处理严重急性呼吸综合征冠状病毒 2 感染，考虑到现有文献，对于现有数据不足以提供充分指导的主题，我们根据情况提供我们的意见我们的临床专业知识和经验。诊断方法包括用于聚合酶链反应测试的鼻咽拭子和对有疾病进展风险的有症状患者进行胸部计算机断层扫描。预防措施包括严格的感染控制方案并优先为患者及其家人接种疫苗。关于对患有 COVID-19 的白血病患者进行化疗或造血细胞移植的决定需要仔细考虑诸如 COVID-19 严重程度和治疗紧迫性等因素。治疗方案包括早期开始抗病毒治疗，使用尼马瑞韦/利托那韦或瑞德西韦。对于长时间病毒脱落的情况，区分活病毒和非活病毒仍然具有挑战性，但对于确定传染性和指导管理决策至关重要。总体而言，考虑免疫状态、临床表现和病毒动力学的个体化方法对于有效管理白血病患者的 COVID-19 至关重要。© 2024 作者。移植传染病由 Wiley periodicals LLC 出版。

Among immunocompromised hosts, leukemia patients, and hematopoietic cell transplant recipients are particularly vulnerable, facing challenges in balancing coronavirus disease 2019 (COVID-19) management with their underlying conditions. In this How I Treat article, we discuss how we approach severe acute respiratory syndrome coronavirus 2 infections in daily clinical practice, considering the existing body of literature and for topics where the available data are not sufficient to provide adequate guidance, we provide our opinion based on our clinical expertise and experience. Diagnostic approaches include nasopharyngeal swabs for polymerase chain reaction testing and chest computed tomography scans for symptomatic patients at risk of disease progression. Preventive measures involve strict infection control protocols and prioritizing vaccination for both patients and their families. Decisions regarding chemotherapy or hematopoietic cell transplantation in leukemia patients with COVID-19 require careful consideration of factors such as COVID-19 severity and treatment urgency. Treatment protocols include early initiation of antiviral therapy, with nirmatrelvir/ritonavir or remdesivir. For cases of prolonged viral shedding, distinguishing between viable and non-viable viruses remains challenging but is crucial for determining contagiousness and guiding management decisions. Overall, individualized approaches considering immune status, clinical presentation, and viral kinetics are essential for effectively managing COVID-19 in leukemia patients.© 2024 The Author(s). Transplant Infectious Disease published by Wiley Periodicals LLC.