默克尔细胞癌（MCC）是一种罕见的、高度侵袭性的原始皮肤神经内分泌癌，其起源尚不完全清楚。人们对许多独立的预后因素进行了研究，试图了解哪些是 MCC 组织学诊断报告中最重要的参数。其中，肥大细胞仅在本文之前的一篇论文中进行过研究。我们对病理科 20 年（含 2003 年至 2023 年）期间收到的 13 例 MCC 病例进行了回顾性描述性研究，我们使用全玻片 (WSI) 形态测量分析扫描平台 Aperio Scanscope CS 进行了研究用于肥大细胞的检测和空间分布，使用抗类胰蛋白酶单克隆抗体和抗CD34单克隆抗体来研究微血管的密度。此外，我们使用 MCPyV 大 T 抗原（克隆 CM2B4）的抗体分析了 MCPyV 状态。我们发现肥大细胞密度与局部复发/远处转移/疾病死亡之间存在统计学上显着的相关性（p = 0.008）。据我们所知，我们首先报道，与 MCPyV (  ) MCC 相比，MCPyV ( -) MCC 显示出更高的肥大细胞密度，众所周知后者的侵袭性较低。此外，中位血管密度与复发/转移/疾病死亡没有显着相关性（p = 0.18）。尽管样本量较小，本文仍促使未来研究肥大细胞密度在 MCC 中的作用。© 2024。作者。

Merkel cell carcinoma (MCC) is a rare, highly aggressive, primitive neuroendocrine carcinoma of the skin, the origin of which is not yet fully understood. Numerous independent prognostic factors have been investigated in an attempt to understand which are the most important parameters to indicate in the histological diagnostic report of MCC. Of these, mast cells have only been studied in one paper before this one. We present a retrospective descriptive study of 13 cases of MCC, received at the Department of Pathology over a 20-year period (2003-2023 inclusive) on which we performed a study using whole-slide (WSI) morphometric analysis scanning platform Aperio Scanscope CS for the detection and spatial distribution of mast cells, using monoclonal anti-tryptase antibody and anti-CD34 monoclonal antibody to study the density of microvessels. In addition, we analyzed MCPyV status with the antibody for MCPyV large T-antigen (Clone CM2B4). We found statistically significant correlation between mast cell density and local recurrence/distant metastasis/death-of-disease (p = 0.008). To our knowledge, we firstly reported that MCPyV ( -) MCC shows higher mast cells density compared to MCPyV ( +) MCC, the latter well known to be less aggressive. Besides, the median vascular density did not show no significant correlation with recurrence/metastasis/death-of-disease, (p = 0.18). Despite the small sample size, this paper prompts future studies investigating the role of mast cell density in MCC.© 2024. The Author(s).