口腔粘膜炎 (OM) 是癌症治疗（化疗、放疗、造血细胞移植或联合治疗）的一种常见且令人衰弱的毒性。 OM 与严重的口腔疼痛有关，并对患者的功能和生活质量产生负面影响。此外，OM 还伴有可能产生严重影响的全身并发症。这些局部和系统性后果可能会改变癌症治疗，并增加经济负担。本综述涵盖了 OM 的临床表现和病程、鉴别诊断、临床和经济影响、发病机制、危险因素、评估措施、OM 的生物标志物和预测、管理、新药和治疗方法开发的研究进展以及大数据。 © 2024 Wiley 期刊有限责任公司。

Oral mucositis (OM) is a common and debilitating toxicity of cancer treatments - chemotherapy, radiotherapy, hematopoietic cell transplant, or combinations. OM is associated with severe oral pain and has negative impacts on patient function and quality of life. Additionally, OM has accompanying systemic complications that may have critical implications. These local and systemic consequences can alter cancer treatment, and add an economic burden. This review covers the clinical presentation and course of OM, differential diagnosis, clinical and economic impacts, pathogenesis, risk factors, assessment measures, biomarkers and prediction of OM, management, research advances in the development of new drugs and treatments, and big data.© 2024 Wiley Periodicals LLC.