本研究旨在探讨解毒泻浊益肾汤治疗痛风性关节炎的有效性和安全性。本回顾性研究收集了2022年2月至2023年2月期间的100例痛风性关节炎患者，根据治疗方法的不同，将患者的数据分为对照组和实验组。对照组给予苯溴马隆常规治疗,实验组在对照组基础上加用血毒泻浊益肾汤治疗。治疗效果的评价指标包括血清8-羟基脱氧鸟苷、3-NT、白细胞介素6、白细胞介素10、白细胞介素1β、肿瘤坏死因子-α、C反应蛋白、血沉、尿素氮、肌酐、膝关节功能及疼痛程度评价、中医证候评分、安全性评价。治疗后，实验组总体治疗效果达到98%，而对照组为78%。治疗后各项指标差异具有统计学意义（SS）（P < .05）。在Lysholm评分中，实验组的改善明显优于对照组，差异具有SS（P < .05）。在NRS评分上，实验组治疗前后NRS评分从8.39下降至1.08，而对照组仅下降至3.61。此外，两组患者中医证候分项关节评分均有明显改善。实验组能够有效改善关节疼痛、关节红肿、关节发热、关节活动受限等症状。治疗后，实验组不良反应发生率仅为8%，而对照组不良反应发生率为24%。对受试者治疗过程中不良反应发生率进行统计分析，发现差异具有SS（P < .001）。解毒泻浊益肾汤与苯溴马隆联合治疗可有效改善氧化应激反应，显着降低血尿酸水平。同时，该联合疗法能有效抑制炎症反应，显着缓解膝关节疼痛，促进膝关节功能恢复。该治疗方案毒副作用较低，安全性较高。版权所有©2024 作者。由 Wolters Kluwer Health, Inc. 出版

This study is for exploring the effectiveness and security of Jiedu Xiezhuo Yishen Tang in the treatment of gouty arthritis. This retrospective study collected 100 patients with gouty arthritis between February 2022 and February 2023. According to the different treatment methods, the data of patients were divided into control group and experimental group. The control group received routine treatment with benzbromarone, while the experimental group received additional treatment with Xuedu Xiezhuo Yishen Tang on the basis of the control group. The evaluation indicators for the effectiveness of treatment include serum levels of 8-hydroxydeoxyguanosine, 3-NT, interleukin-6, interleukin-10, interleukin-1β, tumor necrosis factor-α, C-reactive protein, erythrocyte sedimentation rate, urea nitrogen, creatinine, evaluation of knee joint function and pain level, traditional Chinese medicine syndrome score, and safety evaluation. After treatment, the overall treatment effect of the experimental group reached 98%, while the control group was 78%. After treatment, the differences in various indicators possessed statistical significance (SS) (P < .05). In the Lysholm score, the improvement in the experimental group was markedly more excellent than the control group, and the difference possessed SS (P < .05). In the NRS score, the experimental group's NRS score decreased from 8.39 to 1.08 before and after treatment, while the control group only decreased to 3.61. In addition, both groups of patients showed significant improvement in the joint score in the Traditional Chinese medicine syndrome sub-items. The experimental group was able to effectively improve symptoms such as joint pain, joint redness and swelling, joint fever, and limited joint mobility. After treatment, the incidence of adverse reactions in the experimental group was only 8%, while the incidence of adverse reactions in the control group was 24%. After statistical analysis of the incidence of adverse reactions during treatment among the participants, it was found that the difference possessed SS (P < .001). The combination treatment of Jiedu Xiezhuo Yishen Tang and benbromarone can effectively improve oxidative stress response and significantly reduce blood uric acid levels. Meanwhile, this combination therapy can effectively inhibit inflammatory reactions, significantly alleviate knee joint pain, and promote the recovery of knee joint function. This treatment regimen has lower toxic side effects and higher safety.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.