在使用 90Y 微球进行选择性体内放射治疗之前，使用 18F-FMISO PET 对肝脏肿瘤缺氧进行成像。
Imaging of Hypoxia in Liver Tumors With 18F-FMISO PET Before Selective Internal Radiotherapy With 90Y Microspheres.
发表日期：2024 Jul 03
作者：
Cigdem Soydal, Burak Demir, Ecenur Dursun, Gizem Sutcu, Emre Can Celebioglu, Mehmet Sadik Bilgic, Nuriye Ozlem Kucuk
来源：
CLINICAL NUCLEAR MEDICINE
摘要：
缺氧是对放疗和化疗产生耐药性的已知原因。尽管基于缺氧 PET 的外部放射治疗有多项研究，但缺氧对放射栓塞的影响很大程度上未知。在此，我们介绍了来自一项前瞻性研究的 2 例肝细胞癌患者，在治疗前 18F-FMISO PET 上具有不同的病变特征，并且在 18F-FDG PET 上有不同的反应。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。
Hypoxia is a known cause of resistance to radiotherapy and chemotherapy. Although there are multiple studies in external radiation therapies based on hypoxia PET, the effect of hypoxia in radioembolization is largely unknown. Here we present 2 cases of hepatocellular carcinoma patients from a prospective study with different lesion characteristics on pretreatment 18F-FMISO PET and varying responses on 18F-FDG PET.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.