18F-THK5351 对 tau 具有很强的结合亲和力和选择性。然而，与在星形胶质细胞线粒体外膜中高度表达的单胺氧化酶-B 酶发生脱靶结合是可能的。在异柠檬酸脱氢酶野生型胶质母细胞瘤病例中，11C-MET PET 和 18F-THK5351 PET 在肿瘤中表现出摄取增加。相反，在另一例颅内脑膜瘤病例中，MET PET 显示肿瘤中的摄取增加，而 18F-THK5351 PET 显示肿瘤中的摄取没有异常。然而，通过 MRI 区分脑膜瘤和胶质母细胞瘤具有挑战性。 18F-THK5351 PET 可能有助于区分异柠檬酸脱氢酶野生型胶质母细胞瘤和脑膜瘤。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

18F-THK5351 demonstrates a strong binding affinity and selectivity for tau. However, off-target binding with monoamine oxidase-B enzyme, highly expressed in the outer mitochondrial membranes of astrocytes, is possible. In a case with isocitrate dehydrogenase-wildtype glioblastoma, 11C-MET PET and 18F-THK5351 PET exhibited increased uptake in the tumor. Conversely, in another case with intracranial meningioma, MET PET revealed increased uptake in the tumor, whereas 18F-THK5351 PET showed no abnormal uptake in the tumor. However, it is challenging to distinguish meningiomas from glioblastomas on MRI. 18F-THK5351 PET might help differentiate between isocitrate dehydrogenase-wildtype glioblastoma and meningioma.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.