炼油厂工人接触苯，这是众所周知的导致白血病的原因，但炼油厂工人患白血病的结果好坏参半，而且有关工人接触苯的数据有限。炼油厂工人也接触石棉，多项研究表明间皮瘤的风险增加。之前对瑞典三家炼油厂员工进行的一项研究的更新，目的是调查低至中度接触苯时的癌症发病率，尤其是白血病的发病率对在瑞典三个炼油厂工作至少一年的 2264 名男性（1548 名炼油厂操作员）的癌症发病率进行了跟踪调查。工作类型和就业时间是从完整的公司档案中收集的。职业卫生学家与炼油厂合作，利用历史测量数据以及工业卫生变化和技术发展的详细信息，对苯暴露进行了回顾性评估。通过与瑞典癌症登记处的联系，通过 35-47 年的随访检索癌症病例，并计算具有 95% 置信区间 (CI) 的标准化发病率 (SIR)。总共发生了 258 例肿瘤，而预期发生了 240 例肿瘤（SIR 1.07；95% CI 0.95-1.21）。有 10 例白血病病例，全部发生在炼油厂操作员中（SIR 2.4；95% CI 1.18-4.51）。共有三例胸膜间皮瘤病例，其中两例发生在炼油厂操作员中。白血病病例的平均估计累积苯暴露量为 7.9 ppm 年（中位数 4.9，范围 0.1-31.1）。该研究表明，低至中度的平均累积苯暴露量会增加患白血病的风险。局限性包括病例数较少和潜在的接触错误分类。本研究表明，低至中度接触苯的男性炼油厂工人患白血病的风险增加。版权所有 © 2024 作者。由 Elsevier GmbH 出版。保留所有权利。

Oil refinery workers are exposed to benzene, which is a well-known cause of leukaemia, but results on leukaemia in oil refinery workers have been mixed, and the data on workers' exposure is limited. Oil refinery workers are also exposed to asbestos and several studies have shown increased risk of mesothelioma.The objective was to investigate cancer incidence, especially leukaemia, at low to moderate exposure to benzene in an update of a previous study of employees at three Swedish oil refineries.Cancer incidence was followed up in 2264 men (1548 refinery operators) employed at three oil refineries in Sweden for at least one year. Job types and employment times were collected from complete company files. A retrospective assessment of the benzene exposure was performed by occupational hygienists in collaboration with the refineries using historic measurements as well as detailed information on changes in the industrial hygiene and technological developments. Cases of cancer were retrieved by a linkage with the Swedish Cancer Register through 35-47 years of follow-up and standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated.In total, 258 tumors had occurred versus 240 expected (SIR 1.07; 95% CI 0.95-1.21). There were 10 cases of leukaemia, all in refinery operators (SIR 2.4; 95% CI 1.18-4.51). There were three cases of pleural mesothelioma, two of which in refinery operators. The mean estimated cumulative benzene exposure for the cases of leukaemia was 7.9 ppm-years (median 4.9, range 0.1-31.1).The study suggests that low to moderate average cumulative benzene exposure increases the risk of leukaemia. Limitations include the modest number of cases and potential misclassification of exposure.The present study indicated an increased risk of leukaemia in male oil refinery workers with low to moderate exposure to benzene.Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.