丝状伪足广泛分布在细胞表面，以其动态延伸而著称，在无数的生物过程中发挥着关键作用。它们的功能涵盖从机械传感和引导到早期胚胎细胞组织过程中的细胞间通信。丝状伪足在癌症侵袭和病毒传播等致病过程中发挥重要作用。丝状伪足的分子图谱揭示了丝状伪足功能所必需的通用成分。与此同时，最近对控制丝状伪足动力学的生物物理机制的见解为更广泛地研究丝状伪足的生物学功能提供了基础。我们重点介绍了丝状伪足参与发育和发病机制各个阶段的最新发现，并概述了这些细胞结构在一系列细胞活动中的复杂分子和物理特征。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell-cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.Copyright © 2024 Elsevier Ltd. All rights reserved.