自发现以来，电离辐射一直是癌症治疗的关键。尽管IR具有治疗作用，但由于DNA损伤和活性氧的产生，会损害核酸、脂质和蛋白质，因此会引起严重的急性和慢性并发症。虽然癌细胞由于修复损伤的效率低而更容易受到电离辐射的影响，但受辐射区域的健康细胞也会受到影响。发生各种类型的细胞死亡，包括凋亡、坏死、细胞焦亡、自噬依赖性细胞死亡、免疫原性细胞死亡和铁死亡。由铁依赖性脂质过氧化物积累驱动的铁死亡已被认为在放射治疗的治疗效果和并发症中至关重要，并且在各种组织中进行了广泛的研究。本综述旨在总结与辐射相关的铁死亡所涉及的途径、不同器官的发现以及针对铁死亡以减轻其有害影响的药物。© 2024。作者。

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reactive oxygen species, which harm nucleic acids, lipids, and proteins. While cancer cells are more vulnerable to ionizing radiation due to their inefficiency in repairing damage, healthy cells in the irradiated area also suffer. Various types of cell death occur, including apoptosis, necrosis, pyroptosis, autophagy-dependent cell death, immunogenic cell death, and ferroptosis. Ferroptosis, driven by iron-dependent lipid peroxide accumulation, has been recognized as crucial in radiation therapy's therapeutic effects and complications, with extensive research across various tissues. This review aims to summarize the pathways involved in radiation-related ferroptosis, findings in different organs, and drugs targeting ferroptosis to mitigate its harmful effects.© 2024. The Author(s).