对膀胱癌 (BC) 患者尿流改道 (UD) 时间趋势的分析和大陆性尿流改道 (CUD) 预测因素的识别很少，并且缺少大型队列数据。我们的目的是描述接受根治性膀胱切除术 (RC) 的 BC 患者中 UD 的纵向时间趋势和预测因素。我们回顾性分析了从 1986 年至 2022 年接受 RC 的患者收集的机构数据，以描述患者特征和 UD 的变化。主要终点是与 UD 类型相关的患者特征。采用逻辑回归分析确定 CUD 的预测因素。总共纳入 2224 名患者（77.16% 男性，22.84% 女性），平均年龄 66 岁[标准差 (SD)，10.64 岁]。我们观察到平均年龄从 59.86 (10.8) 岁 (1986-1990) 增加到 69.85 (9.99) 岁 (2016-2022) (p < 0.001)。 CUD的比例从43.72%（94/215；1986-1990）逐渐下降到18.38%（86/468；2016-2022）。男性患者[比值比 (OR)：1.92，95% 置信区间 (CI)：1.43-2.57，p < 0.001）、较年轻（OR：0.88，95% CI：0.87-0.89，p < 0.001）且患有RC 之前没有肾积水的患者（OR：2.2，95% CI：1.66-2.92，p < 0.001）更有可能接受 CUD。我们报告了 RC 后最大的欧洲单中心 UD 队列，表明从 CUD 到 UD 的显着转变宫内节育器，伴随着年龄的增长。最后，我们的数据反映了 1980 年代和 1990 年代 Mainz Pouch-I 以及其他结肠袋的发展和丰富经验。© 2024。作者。

Analysis of temporal trends of urinary diversion (UD) and identification of predictive factors for continent urinary diversion (CUD) in patients with bladder cancer (BC) is scarce and data on large cohorts are missing. We aimed to describe longitudinal temporal trends and predictive factors for UD among patients with BC receiving radical cystectomy (RC).We retrospectively analysed institutional data collected from patients undergoing RC from 1986 to 2022 to describe changes in patients' characteristics and UD. Primary end points were patients' characteristics associated with type of UD. Logistic regression analysis was used to determine predictive factors for CUD.In total, 2224 patients (77.16% male, 22.84% female) with a mean age of 66 years [standard deviation (SD), 10.64 years] were included. We observed an increase in mean age from 59.86 (10.8) years (1986-1990) to 69.85 (9.99) years (2016-2022) (p < 0.001). The proportion of CUD gradually declined from 43.72% (94/215; 1986-1990) to 18.38% (86/468; 2016-2022). Patients who were male [odds ratio (OR): 1.92, 95% confidence interval (CI): 1.43-2.57, p < 0.001), younger (OR: 0.88, 95% CI: 0.87-0.89, p < 0.001) and had no hydronephrosis prior to RC (OR: 2.2, 95% CI: 1.66-2.92, p < 0.001) were more likely to receive CUD.We report the largest European single-center cohort of UD after RC, demonstrating a significant shift from CUD to IUD, accompanied by an increasing age. Finally, our data mirrors the development and extensive experience with the Mainz Pouch-I in the 1980's and 1990's together with other colon pouches.© 2024. The Author(s).