前列腺癌是男性最常诊断的癌症之一，也是全世界癌症相关死亡的主要原因。在导致这种疾病的分子过程中，新陈代谢的重量近年来备受关注。肿瘤表现出代谢适应以满足其生物合成的需要。然而，代谢物在支持细胞在挑战性环境中生存或重塑肿瘤微环境方面也发挥着重要作用，因此被认为是癌症的标志。前列腺癌是由雄激素受体信号传导独特驱动的，这一知识也影响了癌症代谢研究的路径。这篇综述提供了关于支持前列腺癌超越雄激素信号传导的代谢适应的全面视角，特别关注肿瘤细胞内在和外在途径。© 2024。作者。

Prostate cancer is one of the most commonly diagnosed cancers in men and is a major cause of cancer-related deaths worldwide. Among the molecular processes that contribute to this disease, the weight of metabolism has been placed under the limelight in recent years. Tumours exhibit metabolic adaptations to comply with their biosynthetic needs. However, metabolites also play an important role in supporting cell survival in challenging environments or remodelling the tumour microenvironment, thus being recognized as a hallmark in cancer. Prostate cancer is uniquely driven by androgen receptor signalling, and this knowledge has also influenced the paths of cancer metabolism research. This review provides a comprehensive perspective on the metabolic adaptations that support prostate cancer progression beyond androgen signalling, with a particular focus on tumour cell intrinsic and extrinsic pathways.© 2024. The Author(s).