当今世界的主要问题之一是癌症，治愈它还有很长的路要走，它给社会人民和政府带来大量的经济和情感成本。乳腺癌 (BC) 和宫颈癌 (CC) 是两种最常见的癌症，是由女性的多种遗传和环境因素引起的。这两种癌症在女性中的发病率高于其他癌症。 microRNA（miRNA）是长度为18至24个核苷酸的非编码RNA分子，在翻译后变化中发挥重要作用。 miRNA 本身分为两类：oncomiR 和肿瘤抑制因子。 OncomiRs 在肿瘤扩张中发挥作用，而肿瘤抑制因子则阻止肿瘤的发展和进展。 miRNA 可以通过调节自噬、细胞凋亡和信号传导等多种途径来控制细胞过程。细胞凋亡是一种程序性细胞死亡，包括内在途径和外在途径，与坏死和铁死亡等其他细胞死亡途径不同。细胞凋亡通过调节受损细胞和衰老细胞的死亡来控制细胞的生长、分化和死亡，而miRNA是调节细胞凋亡的因素之一，又分为促凋亡和抗凋亡两类。我们决定在这项研究中调查 miRNA 与最常见女性癌症（BC 和 CC）细胞凋亡之间的关系。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下公司）的独家许可。

In today's world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a lot of financial and emotional costs to the people of society and governments. Breast cancer (BC) and cervical cancer (CC), two of the most common cancers, are caused by several genetic and environmental factors in women. These two cancers' involvement rate is higher than other cancers in women. microRNAs (miRNAs) are non-coding RNA molecules with a length of 18 to 24 nucleotides, which play an important role in post-translational changes. miRNAs themselves are divided into two categories, oncomiRs and tumor suppressors. OncomiRs have a part in tumor expansion and tumor suppressors prevent tumor development and progress. miRNAs can control cellular processes by regulating various pathways including autophagy, apoptosis, and signaling. Apoptosis is a type of programmed cell death that includes intrinsic and extrinsic pathways and is different from other cell death pathways such as necrosis and ferroptosis. Apoptosis controls the growth, differentiation, and death of cells by regulating the death of damaged and old cells, and since miRNAs are one of the factors that regulate apoptosis, and divided into two categories: pro-apoptotic and anti-apoptotic. We decided in this study to investigate the relationship between miRNAs and apoptosis in the most common women's cancers, BC and CC.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.