旨在调查中度至剧烈体力活动 (MVPA) 和肌肉强化活动 (MSA) 的不同组合与肺癌幸存者的全因死亡率和癌症死亡率之间的关联。这项全国性前瞻性队列研究使用了 2009 年美国国家健康访谈调查的数据-2018年。该研究共有 785 名肺癌幸存者。截至 2019 年 12 月 31 日，参与者与国家死亡指数相关联。使用自我报告的 MVPA 和 MSA 频率数据来获得 4 个相互排斥的暴露类别。应用多变量 Cox 比例风险模型探讨暴露类别与结果之间的关联。研究人群的平均（标准差 [SD]）年龄为 69.1 (11.3) 岁，其中 429 名 (54.6%) 为女性。其中，白人 641 人（81.7%），黑人 102 人（13.0%）。中位随访时间为 3 年（2526 人年），发生 349 例（44.5%）全因死亡和 232 例（29.6%）癌症死亡。与 MVPA < 60 分钟/周和 MSA< 2 次/周组相比，MVPA ≥ 60 分钟/周和 MSA < 2 次/周组的个体的危险比 (HR) 为 0.50（95% CI，0.36-调整协变量后，全因死亡率为 0.69），癌症死亡率为 0.37（95% CI，0.20-0.67）。 MVPA ≥ 60 分钟/周和 MSA ≥ 2 次/周组的患者全因死亡率 HR 为 0.52（95% CI，0.35-0.77），癌症死亡率 HR 为 0.27（95% CI，0.12-0.62）。与 MVPA < 60 分钟/周和 MSA < 2 次/周组相比。我们还确定了两个 MSA 频率亚组之间 MVPA 和结果风险之间明显的非线性关系。这项队列研究表明，较高水平的 MVPA 和 MSA 组合可能与肺癌幸存者死亡风险的最佳降低相关。© 2024。作者（s）。

To investigate the associations of different combinations of moderate to vigorous physical activity (MVPA) and muscle strengthening activity (MSA) with all-cause and cancer mortality among lung cancer survivors.This nationwide prospective cohort study used data from the US National Health Interview Survey 2009-2018. A total of 785 lung cancer survivors were included in the study. Participants were linked to the National Death Index through December 31, 2019. Self-reported MVPA and MSA frequency data were used to obtain 4 mutually exclusive exposure categories. Multivariate Cox proportional hazard models were applied to explore the association between exposure categories and outcomes.The mean (standard deviation [SD]) age of the study population was 69.1 (11.3) years and 429 (54.6%) were female. Among them, 641 (81.7%) were White and 102 (13.0%) were Black. The median follow-up time was 3 years (2526 person-years), and 349 (44.5%) all-cause deaths and 232 (29.6%) cancer deaths occurred. Compared to the MVPA < 60 min/week and MSA < 2 sessions/week group, individuals in the MVPA ≥ 60 min/week and MSA < 2 sessions/week group showed hazard ratios (HRs) of 0.50 (95% CI, 0.36-0.69) for all-cause mortality and 0.37 (95% CI, 0.20-0.67) for cancer mortality after the adjustment of covariates. Those in the MVPA ≥ 60 min/week and MSA ≥ 2 sessions/week group exhibited HRs of 0.52 (95% CI, 0.35-0.77) for all-cause mortality and 0.27 (95% CI, 0.12-0.62) for cancer mortality when compared to the MVPA < 60 min/week and MSA < 2 sessions/week group. We also identified distinct non-linear relationships between MVPA and outcomes risk among two MSA frequency subgroups.This cohort study demonstrated that higher levels of MVPA and MSA combined might be associated with optimal reductions of mortality risk in lung cancer survivors.© 2024. The Author(s).