铜是一种重要的微量元素，在人体各种病理生理过程中发挥作用。铜还充当参与氧化还原反应的过渡金属，有助于产生活性氧（ROS）。在ROS水平持续升高的情况下，会发生氧化应激，这与不同类型的受调节细胞死亡有关。最近发现的铜凋亡是一种铜依赖性调节细胞死亡途径，与其他已知的调节细胞死亡形式不同，引起了癌症治疗领域研究人员的兴趣。在此，目前的工作旨在概述目前对铜凋亡的理解，重点是其通过与铜诱导的氧化应激相互作用的抗癌活性，从而为未来针对细胞死亡模式的治疗方法提供新思路。© 2024。作者。

Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future.© 2024. The Author(s).