热带植物 Turraea delphinensis 中萜类化合物的分离、表征和抗增殖活性。
Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis.
发表日期:2024 Jul 06
作者:
Hayato Kouno, Saidanxia Amuti, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, Masuo Goto, David J Newman, Barry R O'Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
来源:
JOURNAL OF NATURAL PRODUCTS
摘要:
对 Turraea delphinensis Wahlert(楝科)有机提取物中的成分进行分离、结构测定和生物学评价,分离出 51 种次生代谢物,其中包括 14 种新萜类化合物(6 种环阿烷、4 种 tirucallanes/euphanes、3 种柠檬苦素和 7 种柠檬苦素)。 -酮甾醇)。新化合物中,1是第一个具有三氧螺[4.4]壬烷侧链的三萜类化合物,而11-13是第一个在C-1、-3、-6和C-1、-3、-6和4个含氧官能团的17-γ-内酯四降三萜类化合物。 -7。评估了分离的化合物对五种人类肿瘤细胞系(包括长春花碱耐药细胞系)的抗增殖活性。
The isolation, structure determination, and biological evaluation of constituents from the organic extract of Turraea delphinensis Wahlert (Meliaceae) resulted in the isolation of 51 secondary metabolites, including 14 new terpenoids (six cycloartanes, four tirucallanes/euphanes, three limonoids, and a 7-keto sterol). Among the new compounds, 1 is the first triterpenoid with a trioxaspiro[4.4]nonane side chain, while 11-13 are the first 17-γ-lactone tetranortriterpenoids with four oxygenated functional groups at C-1, -3, -6, and -7. The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines, including a vinblastine-resistant cell line.