缺乏子宫内膜癌后最佳随访时间表的证据。该研究的目的是比较术后三年内接受减少随访护理的女性和接受常规指南指导的随访护理的女性对护理的满意度。ENSURE（子宫内膜癌幸存者的随访护理）试验是在荷兰 42 家医院进行的一项非劣效性随机对照多中心试验。干预组接受较少的随访护理（4 次就诊/3 年），而对照组则接受常规随访护理（8-11 次就诊/3 年）。主要结局是对护理的总体满意度、PSQIII 评分、三年随访，非劣效界值为 6。使用了混合线性回归、意向治疗和符合方案分析（如下所示）。 在 316 项研究中包括女性在内，减少随访组（平均 82；SD = 15）对护理的总体满意度并不低于常规随访组（平均 80；SD = 15）组 (B = 1.80(-2.09;5.68) ））。在第 6、12 和 36 个月时，减少随访组中对随访时间表感到满意的女性 (93/94/90%) 比常规随访组 (79/79/82%；p < 0.001；p < 0.001；p = 0.050）。接受较少随访护理的低风险早期子宫内膜癌女性对护理的满意度不低于接受常规随访护理的女性。与通常的随访相比，减少随访组的女性临床就诊次数较少，同时更多地报告对她们的随访时间表感到满意。研究结果表明，减少后续护理可能是新标准，但应根据需要进行调整以满足额外需求。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Evidence on the optimal follow-up schedule after endometrial cancer is lacking. The study aim was to compare satisfaction with care between women who received reduced follow-up care and women who received usual guideline-directed follow-up care for three years after surgery.The ENSURE (ENdometrial cancer SURvivors' follow-up carE) trial was a non-inferiority randomized controlled multicenter trial in 42 hospitals in the Netherlands. The intervention arm received reduced follow-up care (4 visits/3 years), while the control group received usual follow-up care (8-11 visits/3 years). Primary outcome was overall satisfaction with care, PSQIII score, over three years follow-up, with a non-inferiority margin of 6. Mixed linear regression, intention-to-treat and per-protocol analyses (presented below) were used.Among 316 women included, overall satisfaction with care was not lower in the reduced follow-up (mean 82; SD = 15) compared with the usual follow-up group (mean 80; SD = 15) group (B = 1.80(-2.09;5.68)). At 6, 12 and 36 months, more women (93/94/90%) in the reduced follow-up group were satisfied with their follow-up schedule than in the usual follow-up group (79/79/82%; p < 0.001; p < 0.001; p = 0.050).Women with low-risk, early-stage endometrial cancer who received reduced follow-up care were no less satisfied with their care than women receiving usual follow-up care. Compared with usual follow-up, women in the reduced follow-up group had fewer clinical visits and, at the same time, more often reported being satisfied with their follow-up schedule. Findings suggest that reduced follow-up care may be the new standard, but should be tailored to meet additional needs where indicated.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.