导管原位癌 (DCIS) 可进展为浸润性乳腺癌 (IBC)，但通常永远不会进展。由于我们无法准确预测哪些 DCIS 病变会或不会进展为 IBC，所以几乎所有患有 DCIS 的女性都会接受保乳手术辅以放疗，甚至乳房切除术。在一些国家，还规定内分泌治疗。这意味着许多患有非进展性导管原位癌的女性接受了过度治疗。为了减少这种情况，LORD 患者偏好试验 (LORD-PPT) 通过为患有低风险 DCIS 的女性提供治疗和 AS 之间的选择来测试乳房 X 光主动监测 (AS) 是否安全。为此，充分了解 DCIS 至关重要。因此，我们评估了女性对 DCIS 知识与社会人口统计和临床特征的相关性。LORD-PPT 参与者 (N = 376) 在了解自己的情况后，完成了一份调查问卷，评估社会人口统计和临床特征、风险认知、治疗选择和 DCIS 知识。诊断和治疗方案。66% 的参与者知识匮乏（即，正确回答 7 个知识项目中的 ≤3 个）。大多数错误答案涉及高估 AS 的安全性和误解 DCIS 预后风险。总体而言，DCIS 知识得分较高的女性认为她们患 IBC 的风险略高于知识较差的女性 (p = 0.049)。具有较好 DCIS 知识的女性更常选择手术，而大多数知识较差的女性则选择主动监测 (p = 0.049)。我们的研究结果表明，向患者提供的信息还有改进的空间。患者和临床医生的决策支持工具有助于促进有关 DCIS 管理的有效共同决策。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Ductal carcinoma in situ (DCIS) can progress to invasive breast cancer (IBC), but often never will. As we cannot predict accurately which DCIS-lesions will or will not progress to IBC, almost all women with DCIS undergo breast-conserving surgery supplemented with radiotherapy, or even mastectomy. In some countries, endocrine treatment is prescribed as well. This implies many women with non-progressive DCIS undergo overtreatment. To reduce this, the LORD patient preference trial (LORD-PPT) tests whether mammographic active surveillance (AS) is safe by giving women with low-risk DCIS a choice between treatment and AS. For this, sufficient knowledge about DCIS is crucial. Therefore, we assessed women's DCIS knowledge in association with socio-demographic and clinical characteristics.LORD-PPT participants (N = 376) completed a questionnaire assessing socio-demographic and clinical characteristics, risk perception, treatment choice and DCIS knowledge after being informed about their diagnosis and treatment options.66 % of participants had poor knowledge (i.e., answered ≤3 out of 7 knowledge items correctly). Most incorrect answers involved overestimating the safety of AS and misunderstanding of DCIS prognostic risks. Overall, women with higher DCIS knowledge score perceived their risk of developing IBC as being somewhat higher than women with poorer knowledge (p = 0.049). Women with better DCIS knowledge more often chose surgery whilst most women with poorer knowledge chose active surveillance (p = 0.049).Our findings show that there is room for improvement of information provision to patients. Decision support tools for patients and clinicians could help to stimulate effective shared decision-making about DCIS management.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.