组蛋白脱乙酰酶 (HDAC) 是关键的表观遗传调节因子，具有脱乙酰酶功能的转录复合物是细胞核中针对表观基因组的表观遗传辅阻遏复合物之一。带有 HDAC 的辅阻遏物复合物，例如 Sin3 复合物、NuRD 复合物、CoREST 复合物和 SMRT/NCoR 复合物在生物系统中很常见。这些复合物会激活处于孤立状态的原本不活跃的 HDAC。 HDAC 复合物在转录、复制和 DNA 修复等关键生物过程的调节中发挥着至关重要的作用。此外，HDAC复合体功能失调与包括癌症在内的人类疾病有关。人们正在积极寻求针对 HDAC 复合物的治疗策略。因此，阐明 HDAC 复合物的性质和组成对于理解其在生理和病理条件下功能的分子基础以及设计靶向治疗至关重要。本综述介绍了大型多蛋白 HDAC 复合物的关键方面，包括其结构、功能、调节机制、对疾病发展的影响以及在治疗中的作用。版权所有 © 2024。由 Elsevier B.V. 出版。

Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes with deacetylase function are among the epigenetic corepressor complexes in the nucleus that target the epigenome. HDAC-bearing corepressor complexes such as the Sin3 complex, NuRD complex, CoREST complex, and SMRT/NCoR complex are common in biological systems. These complexes activate the otherwise inactive HDACs in a solitary state. HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is implicated in human diseases including cancer. Therapeutic strategies targeting HDAC complexes are being sought actively. Thus, illustration of the nature and composition of HDAC complexes is vital to understanding the molecular basis of their functions under physiologic and pathologic conditions, and for designing targeted therapies. This review presents key aspects of large multiprotein HDAC-bearing complexes including their structure, function, regulatory mechanisms, implication in disease development, and role in therapeutics.Copyright © 2024. Published by Elsevier B.V.