几项研究报告了亚麻籽对炎症生物标志物的益处，而其他研究报告了相互矛盾的发现。因此，这项荟萃分析的目的是评估亚麻籽对成人炎症生物标志物的影响。检索了 Embase、PubMed、Scopus、Web of Sciences 等数据库，检索截止时间为 2024 年 2 月。最终分析纳入 54 项随机对照试验，涉及来自 12 个国家的 3000 名受试者。总体而言，补充亚麻籽可显着降低 C 反应蛋白 (CRP)（SMD = -0.46；95% CI：-0.70，-0.23，P < 0.001；I2 = 82.9%，P < 0.001）和白细胞介素 6 （IL-6）（SMD = -0.64，95% CI：-1.13，-0.16，P = 0.010；I2 = 92.7，P < 0.001）。此外，亚麻籽没有显着改变肿瘤坏死因子α（TNF-α）的浓度（SMD = -0.17；95% CI：-0.63，0.29，P = 0.467；I2 = 92，P < 0.001）。补充亚麻籽可显着降低 CRP 和 IL-6 的血清浓度，但不会降低 TNF-a。因此，这项荟萃分析表明，目前的证据支持亚麻籽在控制炎症方面的潜在益处。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Several studies reported the benefits of flaxseed on inflammatory biomarkers, while others reported conflicting findings. Thus, the aim of this meta-analysis was to assess the impacts of flaxseed on inflammatory biomarkers in adults. Databases including Embase, PubMed, Scopus, and Web of Sciences were searched till February 2024. The 54 RCTs were included in the final analysis, which involved 3,000 individuals from 12 countries. Overall, the flaxseed supplementation had a significant reduction in C-reactive protein (CRP) (SMD = -0.46; 95% CI: -0.70, -0.23, P < 0.001; I2 = 82.9%, P < 0.001), and interleukin 6 (IL-6) (SMD = -0.64, 95% CI: -1.13, -0.16, P = 0.010; I2 = 92.7, P < 0.001). Furthermore, flaxseed did not significantly change the concentration of tumor necrosis factor α (TNF-α) (SMD = -0.17; 95% CI: -0.63, 0.29, P = 0.467; I2 = 92, P < 0.001). Flaxseed supplementation significantly decreased serum concentrations of CRP and IL-6, but not TNF-a. Thus, this meta-analysis suggests that the current evidence supports the potential benefits of flaxseed in managing inflammatory conditions.Copyright © 2024 Elsevier Inc. All rights reserved.