[十二指肠炎拉塞尔小体。幽门螺杆菌以外的实体和关联的回顾]。
[Duodenitis Russell bodies. Review of the entity and associations beyond H. pylori].
发表日期:2024
作者:
Juan José Domínguez Cañete, Irene Platas Moreno
来源:
CYTOKINE & GROWTH FACTOR REVIEWS
摘要:
称为“莫特细胞”的浆细胞呈现称为“罗素体”的非分泌性免疫球蛋白积聚。它的存在与血液肿瘤有关,但也可能出现在慢性炎症过程中。消化道内最常见的情况是与幽门螺杆菌感染相关的胃窦。我们的患者还添加了罕见的胃外病例,其中与幽门螺杆菌的关联性不一致。我们发现与这些病例相关的下消化道和泌尿系统肿瘤经常出现,肿瘤区域循环细胞因子的表达导致浆细胞过度激活,这证明了这一点。这种可能的关联可以引导我们了解有关肿瘤环境的数据,并为我们提供早期诊断或未来的治疗目标。版权所有 © 2024 Sociedad Española de Anatomía Patológica。西班牙爱思唯尔公共部门,S.L.U.版权所有。
Plasma cells known as "Mott cells" present non-secretable accumulations of immunoglobulins called "Russell bodies". Its presence is related to hematological neoplasms, but it can appear in chronic inflammatory processes. The most common occurrence within the digestive tract is the gastric antrum associated with H. pylori infection. Our patient is added the rare extragastric cases where the association with H. pylori is inconsistent. We have found a frequent appearance of lower digestive and urological neoplasms in relation to these cases, justified by the expression of circulating cytokines in the tumor area that lead to the overactivation of plasma cells. This possible association could lead us to know data about the tumor environment and serve us for early diagnosis or future therapeutic targets.Copyright © 2024 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.