老年人的口腔健康问题有所增加。口腔功能减退症有七种症状和体征：口腔不洁、口腔干燥、咬合力下降、舌唇运动功能下降、舌压下降、咀嚼功能下降、吞咽功能下降，后者是口腔脆弱的重要危险因素。最近的研究表明，唾液生物标志物不仅可以用于评估口腔疾病，包括龋齿和牙周炎，还可以用于评估全身性疾病，例如癌症和糖尿病。这项横断面研究调查了口腔功能减退与唾液生物标志物水平之间的关系。这项横断面研究总共纳入了 116 名 65 岁或以上的患者。如果七种测试中的三种或更多体征或症状符合每种测试的标准，则诊断为口腔功能减退症。使用酶联免疫吸附测定法分析从患者收集的唾液中生物标志物的水平。总共，63.8%的患者被诊断为口腔功能减退。多变量线性回归分析显示唾液中钙卫蛋白水平与口腔水分和咀嚼功能显着相关。此外，唾液中8-OHdG水平与舌唇运动功能和口腔卫生水平相关，而唾液AGE仅与舌唇运动功能相关。多元逻辑回归分析显示，唾液中的钙卫蛋白水平与口腔功能减退的患病率显着相关，即使在调整了年龄、性别和牙周状况后也是如此。然而，唾液中的生物标志物水平与参考范围之外的检查次数没有显着关系。钙卫蛋白、8-OHdG 和 AGE 水平与老年人口腔功能减退相关。© 2024。作者。

Oral health problems have increased among older adults. Oral hypofunction is characterized by seven signs and symptoms: oral uncleanness, oral dryness, decline in occlusal force, decline in the movement function of the tongue and lips, decline in tongue pressure, decline in masticatory function, and decline in swallowing function, the latter being a significant risk factors for oral frailty. Recent research has suggested that salivary biomarkers can be used to assess not only oral diseases, including dental caries and periodontitis, but also systemic diseases, such as cancer and diabetes mellitus. This cross-sectional study investigated the relationship between oral hypofunction and the levels of salivary biomarkers.In total, 116 patients, aged 65 years or older, were included in this cross-sectional study. If three or more signs or symptoms in seven kinds of tests met the criteria of each test, oral hypofunction was diagnosed. The levels of biomarkers in the saliva collected from the patients were analyzed using an enzyme-linked immunosorbent assay.In total, 63.8% of patients were diagnosed with oral hypofunction. Multivariable linear regression analysis showed that calprotectin levels in the saliva were significantly related to oral moisture and masticatory function. Furthermore, 8-OHdG levels in saliva were associated with the movement function of the tongue and lips and oral hygiene level, and salivary AGE correlated only with the movement function of the tongue and lips. Multiple logistic regression analysis revealed that calprotectin levels in the saliva were significantly correlated with the prevalence of oral hypofunction, even after adjusting for age, sex, and periodontal status. However, none of the biomarker levels in the saliva had a significant relationship with the number of examinations outside the reference range.Calprotectin, 8-OHdG, and AGE levels are associated with oral hypofunction in older adults.© 2024. The Author(s).