2020 年，宫颈癌 (UCC) 是法国女性第 12 位、全球第 4 位最常见癌症。法国卫生当局希望提高人乳头瘤病毒 (HPV) 疫苗接种和筛查率。年轻女性、她们的家人、卫生专业人员和教师在采取这些措施时仍然面临许多障碍。 2014 年至 2019 年间，国际研究发现 HPV 疫苗接种对 UCC 筛查的影响不一致。 2022 年，对北部加莱海峡地区 25 至 40 岁的女性进行了一项调查，以评估 1) HPV 疫苗接种及其障碍，2) 作为 HPV 疫苗接种状况函数的 UCC 筛查参与情况。数据为使用通过 QR 码分发的匿名在线调查问卷收集了 2022 年 1 月至 6 月在北部加莱海峡地区随机选择的 80 个全科诊所的数据。结果使用 Chi2 检验进行双变量分析，在数字允许的情况下进行多变量分析，并按年龄分组进行分析（敏感性分析）。对 407 份完整的问卷（针对 602 名参与女性）进行了分析。在我们的样本中，2022 年，北部加莱海峡地区 25 至 40 岁的女性中有 41% 接种了 HPV 病毒。经过多变量调整后，不接种疫苗的危险因素为： 符合接种资格的时期在法国疫苗接种初期（2007-2012：比值比 OR = 0.04 [95% CI，0.02-0.09]；2012-2017：OR = 0.5 [0.3-0.8]），从非医疗来源收到的信息（OR = 0.3 [0.2-0.6]），并且缺乏有关疫苗接种的信息（OR = 0.12 [0.05-0.27]）。在我们的样本中，90% 的女性接受了 UCC 筛查。在双变量分析中，面临不接受筛查风险的女性是年龄最小、接种过 HPV 疫苗、非异性恋、独居、接受全科医生妇科随访以及没有定期妇科随访的女性。敏感性分析显示，无论年龄组，与未筛查显着相关的唯一危险因素是缺乏定期妇科随访。通过医学教育和妇科随访，可以提高HPV疫苗接种和UCC筛查的参与率。这项多中心研究受到法国疫苗接种相对年轻的限制，应在 2037 年之后重复进行，以评估疫苗接种对筛查的可能影响。© 2024。作者。

In 2020, uterine cervical cancer (UCC) was the 12th most common cancer among women in France and the 4th worldwide. French health authorities wanted to increase Human Papilloma Virus (HPV) vaccination and screening rates. There were still many barriers to these measures among young women, their families, and health professionals and teachers. Between 2014 and 2019, international studies found inconsistent effects of HPV vaccination on UCC screening. In 2022, a survey was conducted among women aged 25 to 40 in the Nord-Pas-de-Calais region to assess participation 1) in HPV vaccination and its barriers, 2) in UCC screening as a function of HPV vaccination status.Data were collected using an anonymous online questionnaire distributed by QR code in 80 general practices randomly selected in the Nord-Pas-de-Calais region between January and June 2022. Results were analyzed bivariately using the Chi2 test, multivariately when numbers allowed, and in age subgroups (sensitivity analysis).407 complete questionnaires (for 602 participating women) were analyzed. In our sample, 41% of women aged 25 to 40 in the Nord-Pas-de-Calais region were vaccinated against HPV viruses in 2022. The risk factors for non-vaccination, after multivariable adjustment, were: the periods of eligibility for vaccination in the early days of French vaccination (2007-2012: odds ratio OR = 0.04 [95% CI, 0.02-0.09]; 2012-2017: OR = 0.5 [0.3-0.8]), information received from non-medical sources (OR = 0.3 [0.2-0.6]), and absence of information about vaccination (OR = 0.12 [0.05-0.27]). In our sample, 90% of women were screened for UCC. In bivariate analysis, women at risk of not being screened were those who were youngest, had been vaccinated against HPV, were not heterosexual, lived alone, had gynecological follow-up by their general practitioner, and did not have regular gynecological follow-up. Sensitivity analysis showed that the only risk factor significantly correlated with non-screening regardless of age group was lack of regular gynecological follow-up.Participation in HPV vaccination and UCC screening is improved by medical education and gynecological follow-up. This multicenter study, limited by the relative youth of vaccination in France, should be repeated after 2037 to assess the possible effect of vaccination on screening.© 2024. The Author(s).