流感病毒每年都会导致大量感染和住院治疗。在这项研究中，我们的目的是确定影响流感住院时间和进展为急性呼吸衰竭（ARF）的临床和宿主特异性因素。我们对为期五个季节（2018/19 至 2022/23）的前瞻性主动流感监测研究的数据进行了分析。共有1402名流感患者参与分析，其中大多数（64.5%）是儿童（18岁以下），9.1%是老年人。 29.2% 的患者至少存在一种慢性疾病，9.9% 的患者出现 ARF。中位住院时间为 4 天（IQR：3、6 天）。延长住院时间和发生 ARF 的最重要预测因素是极端年龄（婴儿和老年人）、患有慢性疾病（尤其是至少 3 种慢性疾病的积云）以及入院较晚。慢性疾病中，慢性阻塞性肺疾病、心血管疾病、癌症、糖尿病、肥胖和慢性肾脏病与较长的住院时间和ARF的发生密切相关。在此背景下，旨在慢性病管理、促进流感疫苗接种以及提高认识和获得卫生服务的干预措施可能有助于减少流感对罗马尼亚乃至全球的影响。此外，持续监测流感病毒的传播对于限制其在易感人群中的传播至关重要。© 2024。作者。

Influenza viruses are responsible for a high number of infections and hospitalizations every year. In this study, we aimed to identify clinical and host-specific factors that influence the duration of hospitalization and the progression to acute respiratory failure (ARF) in influenza. We performed an analysis of data from a prospective active influenza surveillance study that was conducted over five seasons (2018/19 to 2022/23). A total of 1402 patients with influenza were included in the analysis, the majority of which (64.5%) were children (under 18 years), and 9.1% were elderly. At least one chronic condition was present in 29.2% of patients, and 9.9% of patients developed ARF. The median hospital stay was 4 days (IQR: 3, 6 days). The most important predictors of prolonged hospital stay and development of ARF were extremes of age (infants and elderly), presence of chronic diseases, particularly the cumulus of at least 3 chronic diseases, and late presentation to hospital. Among the chronic diseases, chronic obstructive pulmonary disease, cardiovascular disease, cancer, diabetes, obesity, and chronic kidney disease were strongly associated with a longer duration of hospitalization and occurrence of ARF. In this context, interventions aimed at chronic disease management, promoting influenza vaccination, and improving awareness and access to health services may contribute to reducing the impact of influenza not only in Romania but globally. In addition, continued monitoring of the circulation of influenza viruses is essential to limit their spread among vulnerable populations.© 2024. The Author(s).