过去十年中，早发性结直肠癌的发病率显着增加。尽管是针对老年人建立的，但关于这一独特群体的筛查、治疗和结果方面的社会经济和种族差异的数据有限。从监测、流行病学和最终结果数据库中确定了年龄 <50 岁诊断出原发性结直肠癌的成年人。感兴趣的暴露是基于约斯特指数的社区社会经济地位，约斯特指数是社区经济健康状况的人口普查水平综合得分。通过 χ2 分析进行单变量分析。创建逻辑回归模型来评估社区社会经济地位（Yost 指数五分位数）与就诊时的转移和手术干预的关联。创建了 Kaplan-Meier 和 Cox 比例风险模型。总共确定了 45,660 名早发结直肠癌患者； 16.8% (7,679) 处于社区社会经济地位最低的五分之一。与邻里社会经济地位最高的患者相比，邻里社会经济地位最低的患者出现转移的可能性高出 1.13 倍（95% 置信区间 1.06-1.21），且生存率较低（风险比 1.45，95% 置信区间 1.37-1.53​​）。地位。非西班牙裔黑人患者更有可能出现转移性疾病（比值比 1.11，95% 置信区间 1.05-1.19），因局部或局部疾病接受手术的可能性较小（比值比 0.48，95% 置信区间 0.43-0.53） ，并且比非西班牙裔白人患者的生存率较低（风险比 1.21，95% 置信区间 1.15-1.27）。早发性结直肠癌的社会经济和种族差异涵盖诊断、治疗和生存。随着早发结直肠癌的疾病负担增加，有必要采取干预措施来促进早期诊断和获得手术机会，以提高少数族裔和社区社会经济地位较低的患者的生存率。由爱思唯尔公司出版。

The incidence of early-onset colorectal cancer has increased markedly over the past decade. Although established for older adults, there are limited data on socioeconomic and racial disparities in screening, treatment, and outcomes in this distinct group.Adults with primary colorectal cancer diagnosed at age <50 were identified from the Surveillance, Epidemiology, and End Results database. The exposure of interest was neighborhood socioeconomic status based on the Yost Index, a census-tract level composite score of neighborhood economic health. Univariate analysis was performed with χ2 analyses. Logistic regression models were created to evaluate the association of neighborhood socioeconomic status (Yost Index quintile) with metastasis at presentation and surgical intervention. Kaplan-Meier and Cox proportional hazards models were created.In total, 45,660 early-onset colorectal cancer patients were identified; 16.8% (7,679) were in the lowest quintile of neighborhood socioeconomic status. Patients with the lowest neighborhood socioeconomic status were 1.13 times (95% confidence interval 1.06-1.21) more likely to present with metastases and had lower survival (hazard ratio 1.45, 95% confidence interval 1.37-1.53) compared to those with the highest neighborhood socioeconomic status. Non-Hispanic Black patients were more likely to present with metastatic disease (odds ratio 1.11, 95% confidence interval 1.05-1.19), less likely to undergo surgery for localized or regional disease (odds ratio 0.48, 95% confidence interval 0.43-0.53), and had lower survival (hazard ratio 1.21, 95% confidence interval 1.15-1.27) than non-Hispanic White patients.Socioeconomic and racial disparities in early-onset colorectal cancer span diagnosis, treatment, and survival. As the disease burden of early-age onset colorectal cancer increases, interventions to boost early diagnosis and access to surgery are necessary to improve survival among minorities and patients with low neighborhood socioeconomic status.Published by Elsevier Inc.