金属有机框架（MOF）是一类不断发展的结晶微孔材料，由于其令人惊叹的物理化学性质和简单的制造方法，长期以来引起了人们的研究兴趣。它们巨大的表面积可以成为无数分子粘附的工作场所和潜在传感器矩阵的场所。在过去的十年中，人们一直在探索将它们纳入电化学传感器矩阵中，作为多种疾病的诊断解决方案。本综述重点介绍了基于 MOF 的电化学生物传感器领域的一些最新进展，重点关注各种重要疾病及其对提升传感器性能的重要性。它总结了基于 MOF 的生物传感器，用于监测各种真实基质中与糖尿病、病毒和细菌败血症感染、神经系统疾病、心血管疾病和癌症相关的生物标志物。讨论还补充了大量表格，详细阐述了 MOF 复合探针制造策略及其各自传感参数领域的最新趋势。本文总结了这些材料在生物传感器领域的未来范围，并启发读者了解未来研究范围的最新趋势。本文分类如下：诊断工具 > 生物传感诊断工具 > 诊断纳米设备。© 2024 Wiley periodicals LLC。

Metal Organic Frameworks (MOFs) are an evolving category of crystalline microporous materials that have grabbed the research interest for quite some time due to their admirable physio-chemical properties and easy fabrication methods. Their enormous surface area can be a working ground for innumerable molecular adhesions and site for potential sensor matrices. They have been explored in the last decade for incorporation in electrochemical sensor matrices as diagnostic solutions for a plethora of diseases. This review emphasizes on some of the recent advancements in the area of MOF-based electrochemical biosensors with focus on various important diseases and their significance in upgrading the sensor performance. It summarizes MOF-based biosensors for monitoring biomarkers relevant to diabetes, viral and bacterial sepsis infections, neurological disorders, cardiovascular diseases, and cancer in a wide range of real matrices. The discussion has been supplemented with extensive tables elaborating recent trends in the field of MOF-composite probe fabrication strategies with their respective sensing parameters. The article sums up the future scope of these materials in the field of biosensors and enlightens the reader with recent trends for future research scope. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > Diagnostic Nanodevices.© 2024 Wiley Periodicals LLC.