纳米胶囊能够以高封装含量和高效率封装治疗药物，这对于癌症免疫治疗至关重要。过去，化学交联用于合成纳米胶囊，这可能会阻碍监管审批过程。因此，通过称为“液滴界面烘烤”的过程利用蛋白质变性，消除了化学交联的需要，从而开发出了一类新型蛋白质纳米胶囊。这种外壳中含有抗原的蛋白质纳米胶囊和封装药物的组合显示出细胞免疫反应的增强。© 2024 作者。 《Advanced Science》由 Wiley‐VCH GmbH 出版。

Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high encapsulation content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking is used to synthesize nanocapsules, which can impede the regulatory approval process. Therefore, a new class of protein nanocapsules is developed by eliminating the need for chemical crosslinking by utilizing protein denaturation through a process that is referred to as "baking at the droplet interface". Such protein nanocapsules with antigens incorporated in the shell and a combination of encapsulated drugs showed an enhancement in the immune response of cells.© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.