亨廷顿蛋白相关蛋白 1 (HAP1) 是第一个被发现与亨廷顿蛋白相互作用的蛋白。除大脑外，HAP1还在脊髓、背根神经节、内分泌和消化系统中表达。 HAP1具有多种功能，涉及囊泡运输、受体回收、基因转录和信号转导。 HAP1 与多种神经系统疾病密切相关，包括亨廷顿病、阿尔茨海默病、癫痫、缺血性中风和抑郁症。此外，HAP1已被证明参与癌症和糖尿病的发生。本文概述了 HAP1 的组织分布、细胞定位、功能，并为研究其在疾病中的作用提供了新的视角。版权所有 © 2024 Wu、Wang、Lu、Yan、Zhao、Yang 和 Pan。

Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington's disease, Alzheimer's disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.Copyright © 2024 Wu, Wang, Lu, Yan, Zhao, Yang and Pan.