肝细胞癌（HCC）的发病率和死亡率较高，且治愈难度大，且发病后容易复发。因此，HCC的早期检测和高效治疗是必要的。在本研究中，我们合成了一种尺寸均匀、长期稳定性好、近红外双区（NIR-II）吸收效率高的新型NDI聚合物，可以极大地提高HCC的治疗效率。增强Huh-7荷瘤小鼠静脉注射后的光热疗法（PTT）效果。体外和体内研究表明，NDI聚合物表现出优异的NIR引导PTT治疗效果，抗肿瘤效果约为88.5%，明显的抗转移作用。本研究开发了一种 NDI 聚合物介导的 NIR-II 荧光成像和光热治疗的综合诊断和治疗方式。© 2024 Li et al.

Hepatocellular carcinomas (HCC) have a high morbidity and mortality rate, and is difficult to cure and prone to recurrence when it has already developed. Therefore, early detection and efficient treatment of HCC is necessary.In this study, we synthesized a novel NDI polymer with uniform size, long-term stability, and high near-infrared two-zone (NIR-II) absorption efficiency, which can greatly enhance the effect of photothermal therapy (PTT) after intravenous injection into Huh-7-tumor bearing mice.The in vitro and in vivo studies showed that NDI polymer exhibited excellent NIR-guided PTT treatment, and the antitumor effect was approximately 88.5%, with obvious antimetastatic effects.This study developed an NDI polymer-mediated integrated diagnostic and therapeutic modality for NIR-II fluorescence imaging and photothermal therapy.© 2024 Li et al.