肠道微生物群与血液恶性肿瘤之间的关系引起了人们的广泛关注。随着研究的进展，越来越清楚的是，肠道微生物群的组成可能影响血液系统恶性肿瘤的发病和进展。然而，我们对这种关联的理解仍然有限。在我们的研究中，我们根据门、纲、目、科和属水平的信息将肠道微生物群分为五组。随后，我们从 IEU Open GWAS 项目中获取了常见血液恶性肿瘤的相关数据。然后，我们采用双向孟德尔随机化 (MR) 方法来确定肠道微生物群与血液恶性肿瘤之间是否存在因果关系。此外，我们还进行了双向 MR 分析，以确定这种因果关系的方向性。通过正向和反向 MR 分析，我们发现淋巴白血病的风险与蓝藻门、甲烷杆菌目、甲烷杆菌纲、消化球菌科、蓝藻门的丰度显着相关。甲烷杆菌科 (Methanobacteriaceae) 和 Lachnospiraceae UCG010 属、甲烷短杆菌属 (Methanobrevibacter)、短杆菌属 (Eubacteria brachy group) 和丁酸弧菌属 (Butyrivibrio)。骨髓性白血病的风险与放线菌门、厚壁菌门、双歧杆菌目、梭菌目、放线菌纲、Gammaproteobacteria纲、梭菌纲、双歧杆菌科、梭菌属、霍氏真杆菌属、Blautia属、柯林斯氏菌属、高氏瘤胃球菌属的丰度显着相关组和双歧杆菌。霍奇金淋巴瘤的风险与梭菌目vadinBB60群、消化球菌属和瘤胃球菌科UCG010属的丰度显着相关。恶性浆细胞瘤的风险与Romboutsia属和直肠真杆菌属的丰度显着相关。弥漫性大B细胞淋巴瘤的风险与丹毒梭菌属和产粪真杆菌群的丰度显着相关。成熟T/NK细胞淋巴瘤的风险与疣微菌门、瘤胃球菌科UCG013属、毛梭菌属和直肠真杆菌属的丰度显着相关。最后，骨髓增生性肿瘤的风险与粪球菌3属和霍氏真杆菌群的丰度显着相关。我们的研究为肠道微生物群与血液恶性肿瘤之间的因果关系提供了新的证据，为这些疾病的预防和治疗提供了新的见解和方法。肿瘤。版权所有 © 2024 Chen、Guo、Wang、Feng、Qin、Hu、Lyu 和 Wang。

The relationship between gut microbiota and hematologic malignancies has attracted considerable attention. As research progresses, it has become increasingly clear that the composition of gut microbiota may influence the onset and progression of hematologic malignancies. However, our understanding of this association remains limited.In our study, we classified gut microbiota into five groups based on information at the phylum, class, order, family, and genus levels. Subsequently, we obtained data related to common hematologic malignancies from the IEU Open GWAS project. We then employed a bidirectional Mendelian Randomization (MR) approach to determine whether there is a causal relationship between gut microbiota and hematologic malignancies. Additionally, we conducted bidirectional MR analyses to ascertain the directionality of this causal relationship.Through forward and reverse MR analyses, we found the risk of lymphoid leukemia was significantly associated with the abundance of phylum Cyanobacteria, order Methanobacteriales, class Methanobacteria, family Peptococcaceae, family Methanobacteriaceae, and genera Lachnospiraceae UCG010, Methanobrevibacter, Eubacterium brachy group, and Butyrivibrio. The risk of myeloid leukemia was significantly associated with the abundance of phylum Actinobacteria, phylum Firmicutes, order Bifidobacteriales, order Clostridiales, class Actinobacteria, class Gammaproteobacteria, class Clostridia, family Bifidobacteriaceae, and genera Fusicatenibacter, Eubacterium hallii group, Blautia, Collinsella, Ruminococcus gauvreauii group, and Bifidobacterium. The risk of Hodgkin lymphoma was significantly associated with the abundance of family Clostridiales vadinBB60 group, genus Peptococcus, and genus Ruminococcaceae UCG010. The risk of malignant plasma cell tumor was significantly associated with the abundance of genera Romboutsia and Eubacterium rectale group. The risk of diffuse large B-cell lymphoma was significantly associated with the abundance of genera Erysipelatoclostridium and Eubacterium coprostanoligenes group. The risk of mature T/NK cell lymphomas was significantly associated with the abundance of phylum Verrucomicrobia, genus Ruminococcaceae UCG013, genus Lachnoclostridium, and genus Eubacterium rectale group. Lastly, the risk of myeloproliferative neoplasms was significantly associated with the abundance of genus Coprococcus 3 and Eubacterium hallii group.Our study provided new evidence for the causal relationship between gut microbiota and hematologic malignancies, offering novel insights and approaches for the prevention and treatment of these tumors.Copyright © 2024 Chen, Guo, Wang, Feng, Qin, Hu, Lyu and Wang.