治疗性单克隆抗体 (mAb) 在多种临床适应症中表现出了良好的效果，包括但不限于最近的移植排斥、癌症和自身免疫性疾病。认识到科学界迫切需要快速、轻松地获取有关单克隆抗体 (mAb) 的可靠信息），IMGT®，国际 ImMunoGeneTics 信息系统®，提供独特且宝贵的资源：IMGT/mAb-DB，治疗性单克隆抗体的综合数据库，可通过用户友好的网络界面访问。然而，这种方法限制了更复杂的查询并将信息与其他数据库隔离。为了将 IMGT/mAb-DB 与其他 IMGT 数据库连接起来，我们创建了 IMGT/mAb-KG，这是一个与 IMGT 结构连接的治疗性单克隆抗体的知识图，基因组学数据库。 IMGT/mAb-KG是使用语义网最有效的方法和标准开发的，并从IMGT/mAb-DB获取数据。在互操作性方面，IMGT/mAb-KG重用了生物医学资源中的术语，并连接到相关资源。2024年2月，IMGT/mAb-KG总共包含139,629个三联体，提供对1,489个mAb、约500个靶点和超过500个抗体的访问临床指征。它提供了对单克隆抗体的作用机制、其结构及其各种产品和相关研究的详细见解。链接到其他资源，例如 Thera-SAbDab（治疗性结构抗体数据库）、PharmGKB（关于遗传变异对药物反应影响的综合资源管理知识）、PubMed 和 HGNC（HUGO 基因命名委员会）、IMGT/mAb-KG是单克隆抗体开发的重要资源。用户友好的 Web 界面有助于探索和分析 IMGT/mAb-KG 的内容。版权所有 © 2024 Sanou、Manso、Todorov、Giudicelli、Duroux 和 Kossida。

Therapeutic monoclonal antibodies (mAbs) have demonstrated promising outcomes in diverse clinical indications, including but not limited to graft rejection, cancer, and autoimmune diseases lately.Recognizing the crucial need for the scientific community to quickly and easily access dependable information on monoclonal antibodies (mAbs), IMGT®, the international ImMunoGeneTics information system®, provides a unique and invaluable resource: IMGT/mAb-DB, a comprehensive database of therapeutic mAbs, accessible via a user-friendly web interface. However, this approach restricts more sophisticated queries and segregates information from other databases.To connect IMGT/mAb-DB with the rest of the IMGT databases, we created IMGT/mAb-KG, a knowledge graph for therapeutic monoclonal antibodies connected to IMGT structures and genomics databases. IMGT/mAb-KG is developed using the most effective methodologies and standards of semantic web and acquires data from IMGT/mAb-DB. Concerning interoperability, IMGT/mAb-KG reuses terms from biomedical resources and is connected to related resources.In February 2024, IMGT/mAb-KG, encompassing a total of 139,629 triplets, provides access to 1,489 mAbs, approximately 500 targets, and over 500 clinical indications. It offers detailed insights into the mechanisms of action of mAbs, their construction, and their various products and associated studies. Linked to other resources such as Thera-SAbDab (Therapeutic Structural Antibody Database), PharmGKB (a comprehensive resource curating knowledge on the impact of genetic variation on drug response), PubMed, and HGNC (HUGO Gene Nomenclature Committee), IMGT/mAb-KG is an essential resource for mAb development. A user-friendly web interface facilitates the exploration and analyse of the content of IMGT/mAb-KG.Copyright © 2024 Sanou, Manso, Todorov, Giudicelli, Duroux and Kossida.