患有器质性胃肠道 (GI) 疾病和糖尿病 (DM) 的患者可能伴有肠脑相互作用障碍 (DGBI)。本研究旨在比较患有和不患有自我报告的器质性胃肠道疾病的成人中 DGBI 相容症状的全球患病率。胃肠道疾病或 DM。数据是通过罗马基金会全球流行病学研究（n = 54,127）在 26 个国家进行的基于人群的互联网调查收集的。受试者被询问是否被医生诊断患有胃食管反流病、消化性溃疡、乳糜泻、炎症性肠病（IBD）、憩室炎、胃肠道癌症或糖尿病。未报告感兴趣的器质性诊断的个体被纳入参考组。 DGBI 兼容的症状特征基于罗马 IV 诊断问题。使用混合逻辑回归模型计算优势比（OR [95% 置信区间]）。患有一种所研究的器质性胃肠道疾病与具有任何 DGBI 兼容的症状特征相关，范围从胃肠道癌症的 OR 1.64 [1.33, 2.02] 到或 IBD 中的 3.22 [2.80, 3.69]。这些关联比 DM 更强，OR 1.26 [1.18, 1.35]。对于相应的（例如，IBD 和肠 DGBI）和非相应的（例如，IBD 和食管 DGBI）解剖区域，器质性胃肠道疾病和 DGBI 兼容症状特征之间存在密切联系。大便失禁和乳糜泻之间的联系最强，OR 6.94 [4.95, 9.73]。在调整混杂因素后，相关性减弱，但仍然存在。与一般人群相比，DGBI 兼容的症状特征在患有自我报告的器质性胃肠道疾病和糖尿病的个体中更为常见。在器质性 (GI) 疾病的管理中应考虑这些伴随的 DGBIs 的存在。© 2024 作者。 《联合欧洲胃肠病学杂志》由 Wiley periodicals LLC 代表联合欧洲胃肠病学出版。

Patients with organic gastrointestinal (GI) diseases and diabetes mellitus (DM) can have concomitant disorders of gut-brain interaction (DGBI).This study aimed to compare the global prevalence of DGBI-compatible symptom profiles in adults with and without self-reported organic GI diseases or DM.Data were collected in a population-based internet survey in 26 countries, the Rome Foundation Global Epidemiology Study (n = 54,127). Individuals were asked if they had been diagnosed by a doctor with gastroesophageal reflux disease, peptic ulcer, coeliac disease, inflammatory bowel disease (IBD), diverticulitis, GI cancer or DM. Individuals not reporting the organic diagnosis of interest were included in the reference group. DGBI-compatible symptom profiles were based on Rome IV diagnostic questions. Odds ratios (ORs [95% confidence interval]) were calculated using mixed logistic regression models.Having one of the investigated organic GI diseases was linked to having any DGBI-compatible symptom profile ranging from OR 1.64 [1.33, 2.02] in GI cancer to OR 3.22 [2.80, 3.69] in IBD. Those associations were stronger than for DM, OR 1.26 [1.18, 1.35]. Strong links between organic GI diseases and DGBI-compatible symptom profiles were seen for corresponding (e.g., IBD and bowel DGBI) and non-corresponding (e.g., IBD and esophageal DGBI) anatomical regions. The strongest link was seen between fecal incontinence and coeliac disease, OR 6.94 [4.95, 9.73]. After adjusting for confounding factors, associations diminished, but persisted.DGBI-compatible symptom profiles are more common in individuals with self-reported organic GI diseases and DM compared to the general population. The presence of these concomitant DGBIs should be considered in the management of organic (GI) diseases.© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.