本研究的主要目的是研究香芹酚 (CAR) 在减轻博莱霉素 (BLM) 诱导的肺纤维化 (PF) 方面的潜在功效。 66 只雄性 Wistar 大鼠被分为两个主要组，每组 7 天和 21 天。他们被分为对照组、BLM、CAR 80（仅适用于 21 天组）和 CAR 治疗组。 CAR 治疗组在滴注 BLM（5 mg/kg，气管内）后接受 CAR（20、40 和 80 mg/kg，口服）7 或 21 天。结果表明，BLM显着增加了支气管肺泡灌洗液中的总细胞计数以及中性粒细胞和淋巴细胞的百分比，并降低了巨噬细胞的百分比。 CAR 剂量依赖性地降低总细胞计数以及中性粒细胞和淋巴细胞的百分比。在BLM暴露的大鼠中，CAR显着降低了硫代巴比妥酸反应物质和羟脯氨酸水平，并提高了总硫醇水平以及过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性。此外，CAR 在第 7 天和第 21 天降低了转化生长因子-β1、结缔转化生长因子和肿瘤坏死因子-α。BLM 在第 7 天增加了干扰素-γ，但在第 21 天降低了其水平。然而，CAR 逆转了干扰素-γ。第 7 天和第 21 天的 γ 水平。根据组织病理学结果，BLM 在第 7 天和第 21 天诱导炎症，但对于纤维化的诱导，21 天的研究显示比 7 天的组有更多的纤维化损伤。 CAR显示纤维化损伤得到改善。 CAR 对 BLM 诱导的肺纤维化的作用可能是由于其抗氧化、抗炎和抗纤维化活性。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

The main objective of this study was to investigate the potential efficacy of carvacrol (CAR) in mitigating bleomycin (BLM)-induced pulmonary fibrosis (PF). Sixty-six male Wistar rats were assigned into two main groups of 7 and 21 days. They were divided into the subgroups of control, BLM, CAR 80 (only for the 21-day group), and CAR treatment groups. The CAR treatment groups received CAR (20, 40, and 80 mg/kg, orally) for 7 or 21 days after an instillation of BLM (5 mg/kg, intratracheally). Results indicated that BLM significantly increased total cell count in bronchoalveolar lavage fluid and the percentages of neutrophils and lymphocytes, and reduced the percentage of macrophages. CAR dose-dependently decreased total cell count and the percentage of neutrophils and lymphocytes. CAR significantly reduced thiobarbituric acid reactive substances and hydroxyproline levels and elevated the total thiol level and catalase, superoxide dismutase, and glutathione peroxidase activities in BLM-exposed rats. Furthermore, CAR decreased the transforming growth factor-β1, connective transforming growth factor, and tumor necrosis factor-α on days 7 and 21. BLM increased interferon-γ on day 7 but decreased its level on day 21. However, CAR reversed interferon-γ levels on days 7 and 21. Based on histopathological findings, BLM induced inflammation on days 7 and 21, but for induction of fibrosis, 21-day study showed more fibrotic injuries than the 7-day group. CAR showed the improvement of fibrotic injuries. The effect of CAR against BLM-induced pulmonary fibrosis is possibly due to its antioxidant, anti-inflammatory, and antifibrotic activity.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.