癌症代谢现在是治疗干预的关键领域，针对对肿瘤生长和生存至关重要的独特代谢重编程。本文回顾了通过糖酵解和谷氨酰胺酶抑制剂解决代谢脆弱性的治疗潜力，这些抑制剂会破坏癌细胞的代谢。讨论了肿瘤异质性和适应性耐药等挑战，并采用包括个性化医疗和预测生物标志物在内的策略来提高治疗效果。此外，将饮食和生活方式的改变与代谢目标相结合，强调了改善治疗结果的整体方法。本文还探讨了将这些策略纳入标准护理的好处，强调了更量身定制、更安全的治疗的潜力。总之，利用代谢脆弱性预示着肿瘤学的新时代，将代谢靶向定位在个性化癌症治疗的最前沿，并改变患者护理。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Cancer metabolism is now a key area for therapeutic intervention, targeting unique metabolic reprogramming crucial for tumor growth and survival. This article reviews the therapeutic potential of addressing metabolic vulnerabilities through glycolysis and glutaminase inhibitors, which disrupt cancer cell metabolism. Challenges such as tumor heterogeneity and adaptive resistance are discussed, with strategies including personalized medicine and predictive biomarkers to enhance treatment efficacy. Additionally, integrating diet and lifestyle changes with metabolic targeting underscores a holistic approach to improving therapy outcomes. The article also examines the benefits of incorporating these strategies into standard care, highlighting the potential for more tailored, safer treatments. In conclusion, exploiting metabolic vulnerabilities promises a new era in oncology, positioning metabolic targeting at the forefront of personalized cancer therapy and transforming patient care.Copyright © 2024 Elsevier B.V. All rights reserved.