这项前瞻性队列研究旨在调查 9996 名参与者的睡眠时间与癌症发病率之间的关系，中位随访期为 9 年。对基线时未患癌症的参与者进行了超过 88,790 人年的随访。癌症的发病率和睡眠时间是自我报告的。使用 Cox 比例风险模型分析睡眠时间和癌症发病率之间的关系，并根据各种混杂因素（包括年龄、性别、生活方式因素和合并症）进行调整。在随访期间，325 名参与者被诊断出患有癌症，导致发病率率为每1000人年20.49。调整混杂因素后，总睡眠时间少于 6 小时与癌症风险增加显着相关（HR：1.27；95% CI：1.01-1.61）。这种关联对于消化系统和呼吸系统的癌症尤其强烈（HR：1.41；95% CI：1.03-1.93）。较长的睡眠时间（> 9 小时）表明癌症风险可能会增加，但结果并不总是显着。年龄分层分析显示，每天睡眠不足 6 小时的 60 岁或以下人群的癌症发病率也显着增加，总体癌症风险增加 35%，消化系统和呼吸系统癌症增加 83%。夜间睡眠时间或白天小睡与癌症发病率之间没有发现显着关联。然而，在女性中，白天小睡时间超过 30 分钟与癌症发病率之间存在显着的交互作用 (p = 0.041)。我们观察到，睡眠时间短可能会增加患癌症的风险，特别是消化系统和呼吸系统的癌症。此外，虽然较长的睡眠时间也可能会增加癌症风险，但这一发现需要用更大的样本量进行验证。© 2024。作者。

This prospective cohort study aimed to investigate the relationship between sleep duration and cancer incidence among 9996 participants over a median follow-up period of 9 years.Participants without cancer at baseline were followed for over 88,790 person-years. The incidence of cancer and sleep duration was self-reported. The relationship between sleep duration and cancer incidence was analyzed using Cox proportional hazards models adjusted for various confounding factors, including age, gender, lifestyle factors, and comorbidities.During the follow-up, 325 participants were diagnosed with incident cancer, resulting in an incidence rate of 20.49 per 1000 person-years. After adjusting for confounders, a total sleep duration of less than 6 h was significantly associated with an increased risk of cancer (HR: 1.27; 95% CI: 1.01-1.61). This association was particularly strong for cancers in the digestive and respiratory systems (HR: 1.41; 95% CI: 1.03-1.93). Longer sleep durations (> 9 h) showed a potential increase in cancer risk, but results were not consistently significant. Age-stratified analyses revealed a similar significant increase in cancer incidence among individuals aged 60 years or younger with less than 6 h of sleep per day, showing a 35% increase in overall cancer risk and an 83% increase in digestive and respiratory system cancer. No significant association was found between nocturnal sleep durations or daytime naps and cancer incidence. However, a significant interaction was observed between daytime naps longer than 30 min and cancer incidence in women (p = 0.041).We observed that short sleep duration may increase the risk of cancer, particularly cancers in the digestive and respiratory systems. Additionally, while longer sleep durations might also increase cancer risk, this finding requires validation with larger sample sizes.© 2024. The Author(s).