旨在评估 65 岁及以上诊断为甲状腺乳头状癌（PTC）的老年患者颈部淋巴结转移的危险因素。在这项回顾性分析中，我们总共纳入了 328 名 65 岁及以上诊断为 PTC 的老年患者。我们彻底检查了这些患者的临床特征。利用单变量和多变量逻辑回归分析，我们旨在确定 65 岁及以上特定 PTC 患者人群中导致中央和侧方淋巴结转移 (CLNM/LLNM) 风险的因素。在单变量分析中，CLNM 显着与肿瘤大小、多灶性、双侧性和微钙化相关，而仅肿瘤大小≥ 1cm（OR = 0.530，P = 0.019，95% CI = 0.311 - 0.900）和多灶性（OR = 0.291，P < 0.001，95% CI = 0.148 - 0.574）在多变量分析中仍然是危险因素。 LLNM 被证实与男性相关（OR = 0.454，​​P < 0.020，95% CI = 0.233 - 0.884），肿瘤大小≥ 1cm（OR = 0.471，P = 0.030，95% CI = 0.239 - 0.928），年龄≥ 70（OR = 0.489，P = 0.032，95% CI = 0.254 - 0.941），多变量分析中微钙化（OR = 0.384，P = 0.008，95% CI = 0.189 - 0.781）。在患有 CLNM 的老年 PTC 患者中，男性（OR = 0.350，P = 0.021，95% CI = 0.143 - 0.855），年龄 ≥ 70（OR = 0.339，P = 0.015，95% CI = 0.142 - 0.810），双侧性在单变量和多变量分析中（OR = 0.320，P = 0.012，95% CI = 0.131 - 0.779）与伴随的 LLNM 密切相关。对于 65 岁及以上的老年 PTC 患者，肿瘤大小 ≥ 1cm 和多灶性是CLNM。同时，男性、肿瘤大小≥1cm、年龄≥70岁和微钙化是LLNM的重要预测因素。在已诊断为 CLNM 的患者中，男性、年龄 ≥ 70 岁和双侧性会增加 LLNM 的风险。版权所有 © 2024 张、吉、杨和王。

To assess the risk factors of cervical lymph node metastasis in elderly patients aged 65 years and older diagnosed with papillary thyroid cancer (PTC).In this retrospective analysis, we included a total of 328 elderly patients aged 65 years and older diagnosed with PTC. We thoroughly examined clinical features from these patients. Utilizing univariate and multivariate logistic regression analyses, we aimed to identify factors contributing to the risk of central and lateral lymph node metastasis (CLNM/LLNM) in this specific population of PTC patients aged 65 years and older.In the univariate analysis, CLNM was significantly associated with tumor size, multifocality, bilaterality, and microcalcification, while only tumor size ≥ 1cm (OR = 0.530, P = 0.019, 95% CI = 0.311 - 0.900) and multifocality (OR = 0.291, P < 0.001, 95% CI = 0.148 - 0.574) remained as risk factors in the multivariate analysis. LLNM was confirmed to be associated with male (OR = 0.454, P < 0.020, 95% CI = 0.233 - 0.884), tumor size ≥ 1cm (OR = 0.471, P = 0.030, 95% CI = 0.239 - 0.928), age ≥ 70 (OR = 0.489, P = 0.032, 95% CI = 0.254 - 0.941), and microcalcification (OR = 0.384, P = 0.008, 95% CI = 0.189 - 0.781) in the multivariate analysis. In elderly PTC patients with CLNM, male gender (OR = 0.350, P = 0.021, 95% CI = 0.143 - 0.855), age ≥ 70 (OR = 0.339, P = 0.015, 95% CI = 0.142 - 0.810), and bilaterality (OR = 0.320, P = 0.012, 95% CI = 0.131 - 0.779) were closely associated with concomitant LLNM in both univariate and multivariate analyses.For elderly PTC patients aged 65 and older, tumor size ≥ 1cm and multifocality are significant risk factors for CLNM. Meanwhile, male, tumor size ≥ 1cm, age ≥ 70, and microcalcification are crucial predictors for LLNM. In patients already diagnosed with CLNM, male, age ≥ 70, and bilaterality increase the risk of LLNM.Copyright © 2024 Zhang, Ji, Yang and Wang.