在世界范围内，鳞状细胞癌（SCC）的发病率正在上升。文献争论人乳头瘤病毒 (HPV) 在皮肤鳞状细胞癌发展中的作用。在本研究中，我们检查了鳞状细胞癌样本中的 HPV 组织病理学。 2020年三级转诊皮肤中心的回顾性研究。在SCC标本中检查了HPV的组织病理学特征，包括空细胞增多、角化过度、棘层肥厚、颗粒过多、角化不全、日光弹力组织增生、乳头状瘤病和肿瘤分级。两名皮肤病理学家独立地重新评估了所有样本。我们检查了 331 例 SCC 病例（男性：女性比例 = 3.9：1）。平均年龄为 68.1 岁，标准差为 15.1。病变最常见于面部（40.5%）、头皮（22.7%）和四肢（20.8%）。在 50 个（15.1%）病变处发现了挖空细胞。指甲（38.1%，p=0.007）、口腔（36.8%，p=0.014）和生殖器（60.0%，p=0.026）病变的空细胞率较高。 6.6% 的标本中发现鳞状细胞癌，但原位肿瘤的挖空细胞率最高 (64.7%)，显着高于其他级别 (p<0.001)。 SCC 病理学常显示 HPV 和特定的挖空细胞组织病理学。分化良好的鳞状细胞癌与指甲、口腔和生殖器病变具有更强的关联性。版权所有 © 2024，作者。

Worldwide, squamous cell carcinoma (SCC) incidence is rising. The literature debates the human papillomavirus (HPV)'s role in cutaneous SCC development. We examined HPV histopathology in SCC samples in this study. Retrospective study at tertiary referral skin center in 2020. Histopathological features of HPV, including koilocytosis, hyperkeratosis, acanthosis, hypergranulosis, parakeratosis, solar elastosis, papillomatosis, and tumor grade, were examined in SCC specimens. Two dermatopathologists independently reevaluated all samples. We examined 331 SCC cases (male:female ratio = 3.9:1). The mean age was 68.1, with 15.1 standard deviation. Lesions were most common on the face (40.5%), scalp (22.7%), and extremities (20.8%). Koilocytes were found in 50 (15.1%) lesions. Nail (38.1%, p=0.007), oral cavity (36.8%, p=0.014), and genitalia (60.0%, p=0.026) lesions had higher koilocytosis rates. SCCs were found in 6.6% of specimens, but in situ tumors had the highest koilocytosis (64.7%), significantly higher than other grades (p<0.001). SCC pathology often shows HPV and specific koilocyte histopathology. Well-differentiated SCC has a stronger association with nail, oral, and genital lesions.Copyright © 2024, the Author(s).